Todd Wylie

Assistant Professor of Pediatrics

Todd Wylie is an Assistant Professor in the Department of Pediatrics, Division of Gastroenterology, Hepatology & Nutrition, and the McDonnell Genome Institute at Washington University School of Medicine. He develops/utilizes bioinformatics methods and tools for the analysis of high throughput multi-omics data. Mr. Wylie has more than 20 years of experience in large-scale genomics, biology applications, informatics, and analytics across a wide range of scientific disciplines. He is highly experienced in the technology development and informatics operations of large genome centers.

Early in his career, Mr. Wylie contributed to the International Human Genome Sequencing Consortium that sequenced and mapped the first human genome. Subsequently, he has contributed to the sequencing and analysis of other landmark model organisms, including mouse, macaque, platypus, soybean, zebrafish, toxoplasma, and numerous parasitic and free-living nematode species. Mr. Wylie contributed his expertise and analytical skills to the sequencing and publication of the first human cancer genome from a patient with acute myeloid leukemia, and subsequent projects on human cancer sequencing data. He worked for nine years in the area of technology development under Dr. Elaine R. Mardis, then Co-Director of The McDonnell Genome Institute, managing a small, agile group of bioinformaticians. In this role, he functioned as the informatics/analysis “glue” between the wet lab, bioinformatics team, testing and training, and other collaborative groups at the institute. He has extensive experience handling and analyzing high-throughput sequencing data produced by multiple next-generation sequencing platforms.

Before joining the Department of Pediatrics, Mr. Wylie directed Dr. George Weinstock’s microbial computing group, focusing on software development and analysis for the study of human and microbial genomes during the Human Microbiome Project (HMP). In addition to being an accomplished computer programmer, Mr. Wylie has an extensive background in metagenomics, transcriptomics, and the analysis of other multi-omics data. Mr. Wylie’s current focus is to collaborate with clinicians and basic scientists in improving medical practice through the application of high-throughput multi-omics and associated computational methods. He is involved in many collaborative efforts studying the microbiome and its association with disease in infants and children. Mr. Wylie and colleagues recently developed a comprehensive targeted-sequence capture panel called ViroCap, which enriches nucleic acid from DNA and RNA viruses.

Todd Wylie’s publications