Obi L. Griffith, PhD

MGI Assistant Director

Assistant Professor of Medicine

Dr. Griffith’s research is focused on the development of personalized medicine strategies for cancer using genomic technologies. Specifically, he develops bioinformatics and statistical methods for the analysis of high throughput sequence data and identification of biomarkers for diagnostic, prognostic, and drug response prediction.

Dr. Obi Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has spent the past 15 years developing methods in data mining, genomics, and bioinformatics for application to cancer precision medicine. He received his PhD in Medical Genetics from the University of British Columbia and completed postdoctoral fellowships at the BC Cancer Agency and Lawrence Berkeley National Laboratories. He was Genome Fellow and then Research Faculty at the McDonnell Genome Institute before starting his own laboratory.

His research is focused on the development of personalized medicine strategies for cancer using genomic technologies. Specifically, he develops bioinformatics and statistical methods for the analysis of high throughput sequence data and identification of biomarkers for diagnostic, prognostic, and drug response prediction. He also devotes substantial time to bioinformatics training as an instructor for the Advanced Sequencing Technologies & Applications course at Cold Spring Harbor Laboratories, Informatics for RNA-seq Analysis for the Canadian Bioinformatics Workshops series, and online tutorials.

Dr. Griffith has received research awards and honors from Atomic Energy of Canada Ltd., Natural Sciences and Engineering Research Council, University of Winnipeg, University of British Columbia, Michael Smith Foundation for Health Research, Canadian Institutes of Health Research, British Columbia Cancer Agency and the US National Academy of Sciences. He was profiled in Maclean’s magazine as one of Canada’s 25 ‘Best and Brightest’ for his contribution to the sequencing of the SARS virus genome, as an ‘up and coming’ investigator in Genome Technology Magazine and in Wired Magazine’s Annual ‘Smart List’. He recently completed an NCI K22 Transition Career Development Award to study the regulatory mutational landscape of breast cancer and most recently was awarded an NCI U01 for Development of Informatics Resources for Interpretation of Clinically Actionable Variants in Cancer.

Dr. Griffith has published over 90 papers with areas of focus in breast cancer, thyroid cancer, OSCC, precision medicine, cancer genomics, cancer immunology, cancer biomarkers, sequence analysis, gene regulation, gene expression, bioinformatics, knowledge bases and biocuration. He is a strong advocate for open access and open source science, having led development of a number of popular bioinformatics tools (CIViC, DGIdb, DoCM, GenVisR), and made major contributions to online educational resources for bioinformatics (rnaseq.wiki, genviz.org, biostars.org).

Dr. Griffith’s publications

Dr. Griffith’s website