Malachi Griffith, PhD

MGI Assistant Director

Assistant Professor of Medicine

Dr. Griffith’s research is focused on the development of personalized medicine strategies for cancer using genomic technologies. Specifically, he develops bioinformatics methods for the analysis of high throughput sequence data to identify biomarkers for response and understand mechanisms of resistance. Immunogenomics and personalized cancer immunotherapy has become a major focus of his research program.

Dr. Griffith is Assistant Professor of Medicine and Assistant Director of the McDonnell Genome Institute at Washington University School of Medicine. He has spent the past 15 years developing methods in data mining, genomics, and bioinformatics for application to cancer precision medicine.

He received his PhD in Medical Genetics from the University of British Columbia and completed a postdoctoral fellowship at the BC Cancer Agency. He was Genome Fellow and then Research Faculty at the McDonnell Genome Institute before starting his own laboratory. He also devotes substantial time to bioinformatics training as a workshop instructor for
Cold Spring Harbor Laboratories courses, the Canadian Bioinformatics Workshops series, and open access online tutorials. He has created and taught workshops covering RNA sequencing, advanced sequencing technologies and applications, genomic data visualization, and precision medicine. To date, he has been an instructor for more than 20 workshops attended by more that 500 students. More than 100,000 people have viewed online video recordings and other materials for these courses.

Dr. Griffith has received research awards and honors from Atomic Energy of Canada Ltd., Natural Sciences and Engineering Research Council, University of Winnipeg, University of British Columbia, Michael Smith Foundation for Health Research,Terry Fox Foundation, National Cancer Institute of Canada, British Columbia Cancer Agency and National Institutes of Health. He was profiled as an ‘up and coming’ investigator in Genome Technology Magazine and in Wired Magazine’s Annual ‘Smart List’. He recently completed an NHGRI K99 Career Development Award to study regulatory and splicing variation in cancer by integration of genome and transcriptome data. In May 2017 he transition to the R00 phase of this award.

Dr. Griffith has published over 70 papers with areas of focus in breast cancer, colon cancer, AML, ALL, precision medicine, cancer genomics, cancer immunology, neoepitope characterization, cancer biomarkers, sequence analysis, gene expression,alternative splicing, bioinformatics, and variant knowledge bases. He is a strong advocate for open access and open source science, having led development of a number of popular bioinformatics tools (e.g. CIViC, DGIdb, GenVisR, pVACTools, RegTools), and made major contributions to online educational resources for bioinformatics (e.g. rnabio.org, genviz.org, pmbio.org, biostars.org, etc.).

Dr. Griffith’s publications

Dr. Griffith’s website