Projects
Center for Common Disease Genomics
Collaborative large-scale genome sequencing effort comprehensively identifying rare risk and protective variants that contribute to common disease phenotypes
CIViC: Clinical Interpretations of Variants in Cancer
An open access, open source, community-driven web resource with the goal of enabling cancer precision medicine
Detail molecular profiling of neurodegenerative diseases and precision medicine
Neurodegenerative diseases, including Alzheimer's disease (AD) or Parkinson's Disease (PD) are complex polygenic diseases with genetic, cellular, pathologic, and clinical heterogeneity.
DGIdb: Drug Gene Interaction Database
User-friendly database with information on drug-gene interactions
GRC: Genome Reference Consortium
Improving the sequence quality and accuracy of the human reference genome
Human Genome Project
As part of this national effort to decode the human genome, the McDonnell Genome Institute contributed more than 20% of the draft sequence
Human Microbiome
The McDonnell Genome Institute helped to characterize the body's microbial communities, or microbiome
Pediatric Cancer Genome Project
St. Jude Children's Research Hospital and MGI teamed up to decode the genomes of more than 600 childhood cancer patients
Reference Genome Improvement
The McDonnell Genome Institute is committed to enhancing and diversifying human reference genomes.
TCGA: The Cancer Genome Atlas
A comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer
TOPMed: Trans-Omics for Precision Medicine
Understanding the genetics underlying heart, lung, blood and sleep disorders, including chronic obstructive pulmonary disease