The Elizabeth H. and James S. McDonnell III Genome Institute provides comprehensive genomic services to Washington University and the scientific community.

Leading the way in high-speed, comprehensive genomics.

We aim to improve the human condition by producing, studying and interpreting high-quality genome-based data that drives biological discoveries.

A Team of Experts


Li Ding, PhD, led a team that analyzed DNA from nearly 10,000 patient tumors across 33 cancer types. They found 300 genes that drive cancer, and more than half of the tumors analyzed had at least one mutation of clinical significance.

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Over $1.3B in Research Funding


The McDonnell Genome Institute has received over $1.3 billion in research funding to inform future clinical work and help in the study, diagnosis and treatment of disease.

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Latest News


WUSTL-led Team Compiles Human Structural Variant Resource

“A team led by Washington University in St. Louis researchers has profiled rare and ultra-rare structural variants in nearly 18,000 high-coverage whole-genome sequences in an effort to fill in remaining gaps in the understanding of the larger variants that impact protein-coding and non-coding portions of the genome.”

$5 million supports research into neglected tropical diseases

“Led by Makedonka Mitreva, PhD, a professor of medicine and of genetics, both projects involve large-scale genome sequencing of the parasites to develop genetic tools to help monitor the infections’ spread and track resistance these parasites already have developed against drugs intended to eradicate them. “ https://medicine.wustl.edu/news/5-million-supports-research-into-neglected-tropical-diseases/

School of Medicine physicians, researchers tackle coronavirus

Clinical teams ready; research for vaccines, drugs underway “geneticist Ting Wang, PhD, the Sanford and Karen Loewentheil Distinguished Professor of Medicine, and members of his lab built a genome browser to help researchers study the genetics of the COVID-19 virus and compare different strains.”
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