Cancer Genomics
Genomics of AML
In 2008, a team led by Dr. Timothy Ley became the first to sequence an entire cancer genome using a patient’s own cancerous cells. The cancer they chose to sequence first was Acute Myeloid Leukemia (AML).
AML Genomics and Chemotherapy
AML Genomics in Diagnosis
New AML Mutation Discovered
Genomics of Breast Cancer
Breast cancer has become one of the more well-characterized cancers, particularly from a molecular and genetic standpoint. Thanks to a number of in-depth genetic analyses, the disease has been classified into four distinct sub-types, including luminal A, luminal B, basal-like, and Her2-positive. Researchers at The Genome Institute are focusing on the sequencing and analysis of basal-like tumors, which are among the most aggressive breast tumors.
DNA of 50 breast cancer patients decoded
Genomics of a Mouse Cancer Model
Scientists at The Genome Institute and colleagues, who pioneered sequencing the genomes of cancer patients to find novel genetic changes at the root of the disease, have now turned their attention to a laboratory workhorse — a mouse.
Sequencing Helps Identify Cancer Cells for Immune System Attack
Genomics of Liver Cancer
Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is the second leading cause of cancer-related death in men worldwide. Researchers at The Genome Institute and colleagues are teaming up to study the genetics of HCC.
Other Cancers
The Genome Institute is involved in a number of other cancer sequencing projects.
Pediatric Cancer Genome Project
St. Jude Children's Research Hospital and The Genome Institute at Washington University School of Medicine in St. Louis have joined forces to decode the genomes of more than 600 childhood cancer patients. The St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project is the largest investment to date - estimated to cost $65 million over three years - aimed at understanding the genetic origins of childhood cancers. Scientists involved in the project will sequence the entire genomes of both normal and cancer cells from each patient, comparing differences in the DNA to identify genetic mistakes that lead to cancer.
Gene Linked to Fatal Neuroblastoma in Adolescents, Young AdultsDiscovery of Mutations Tied to Aggressive Childhood Brain TumorsNew Drug Target for Childhood Eye Tumor
Progress in Fight Against Aggressive Childhood Leukemia
The Cancer Genome Atlas
The importance of genomics in the study of cancer has prompted the initiation of The Cancer Genome Atlas (TCGA) project, a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing.
Washington University Cancer Genome Initiative
The primary aim of the Washington University Cancer Genome Initiative (WUCGI) is to sequence the tumor and normal genomes from 150 cancer patients (for a total of 300 complete genomes).
Research Areas
