|St. Louis Business Journal||Washington University Receives $10 million for DNA Sequencing Research||2017-06-22|
|New York Times||Rare Gene Mutations Inspire New Heart Drugs||2017-05-24|
|Smithsonian Magazine||Lend Me Your Ears: A Tale of Evolution From a 5,310-Year-Old Corn Cob||2016-11-18|
|Christian Science Monitor||Tarsier Genome Offers Clues About Our Oddball Primate Relative||2016-10-10|
|GRC Co-Hosting Free Workshop at ASHG||2016-10-06|
|St. Louis Business Journal||Washington University Receives $10 million Gift for Immune System Research||2016-09-28|
|WUSTL News||Faculty Team Awarded $1.25 Million to Study ‘Swimming Cells’||2016-09-07|
|MGI||Announcing the CIViC Hackathon & Curation Jamboree at NKI in Amsterdam Nov 30 - Dec 2||2016-09-06|
|GenomeWeb||Teams Describe Mutations Tied to Lower Triglyceride Levels, Reduced Coronary Artery Disease Risk||2016-03-03|
|BioTechniques||When Two is Better Than One||2016-02-03|
|Science Magazine||Avian Supergenes||2016-01-29|
|St Louis Business Journal||Wash U, SLU Line Up with Biden’s ‘Cancer Moonshot’||2016-01-22|
|Stat News||NIH Pumps $260m Into Search for Disease Genes That Matter||2016-01-15|
|STL Today||Wash U Part of $240 Million Effort to Map 200,000 Genomes for Clues to Common Diseases||2016-01-14|
|New York Times||‘Moonshot’ to Cure Cancer, to Be Led by Biden, Relies on Outmoded View of Disease||2016-01-13|
|STL Today||STL Cancer Expert Attends White House Health Meeting||2016-01-11|
|Stat News||Biden Staff to Cancer Researchers: Tell Us What We Can Do Quickly||2016-01-08|
|Independent||Study of 12 Types of Cancer Sheds Light on How Disease is Inherited||2015-12-23|
|Huffington Post||Many Children with Cancer Were Born with Genes That Increase Risk||2015-11-19|
|Health News Digest||Cleft Lip and Palate Project Among the First Selected Under Federal Pediatric Research Act||2015-11-18|
|Cancer Research Foundation||Obi Griffith Receives 2015 Cancer Research Foundation Young Investigator Award||2015-11-03|
|The New Yorker||Are Cats Domesticated?||2015-10-23|
|STL Today||Cancer Vaccines Enter Clinical Trials||2015-10-18|
|GenomeWeb||WUSTL's Ding Touches on Value of Deep Tumor, Relapse Sample Sequencing at ASHG||2015-10-09|
|ASHG TV||Cancer Genetics in the Genomics Era - ASHG 2015||2015-10-09|
|NIH News||NIH Common Fund launches Four Programs Designed to Take Aim at Gaps in Biomedical Research||2015-10-05|
|KPLR11||A Panel Discussion on Breast Cancer and New Treatments||2015-10-05|
|Nature News||Human Genome Project: Twenty-Five Years of Big Biology||2015-10-05|
|GenomeWeb||WUSTL Team Develops Virome Capture Technique||2015-09-29|
|CSH Molecular Case Studies||Dr. Wartman: A Case of Me||2015-09-25|
|Huffington Post||Is Cancer in the Family Tree?||2015-09-25|
|Fox2Now||Cyclists Stand Up to Cancer||2015-09-25|
|Outlook Magazine||Collaborative Visionary: Dean Larry Shapiro||2015-09-25|
|Doctor's Lounge||Genomic Approach Could Aid Risk Stratification in Adults With AML||2015-08-27|
|GenomeWeb||WUSTL Team Begins Testing Platform for Sharing Summaries on Clinically Relevant Cancer Variants||2015-07-23|
|Slate||Are Cats Really Wild Animals?||2015-07-05|
|Front Line Genomics||Building an Open Access Forum for N of 1 Studies||
Molecular Case Studies, Editor-In-Chief, Elaine Mardis tells us the story behind the new journal ahead of its launch later this year.
|AACR Cancer Research Catalyst Blog||Q&A with Elaine R. Mardis, PhD, on Integrating Clinical Genomics and Cancer Therapy||2015-06-12|
|Why Is Your Cat Such a Picky Eater? Scientists Reveal Clues||2015-06-04|
|Nature News||Medical Research: Subject to Reflection||2015-05-28|
|New Zealand 3 News||Cancer Vaccine Preliminary Trials Working||2015-05-25|
|St. Louis Science Center||Genome: Unlocking Life's Code Opens at STL Science Center||2015-05-15|
|Forbes||IBM's Watson Enters Market For Analyzing Cancer Genetics||2015-05-05|
|Shape Magazine||DNA-Based Personalized Medicine May Change Healthcare Forever||2015-05-01|
|Outlook Magazine||New Name, New Era||2015-04-30|
|Smithsonian Magazine||Ask Smithsonian: Are Cats Domesticated?||2015-04-30|
|STL Today||New Tech at Wash U Maps Human Genome in Days; Large-scale Studies Now Possible||2015-04-25|
|Melanoma News Today||Researchers Discover Genetic Alterations in Children and Adolescents with Melanoma||2015-04-14|
|Bioscience Technology||The First Personalized Genomic Cancer Vaccines||2015-04-14|
|WUSTL Newsroom||Maher Receives Susan G. Komen Career Award||2015-04-03|
|NineNet||Cancer: Stay Tuned||2015-03-30|
|GenomeWeb||Dr. Mardis to Serve as Editor-in-Chief for New Precision Medicine Journal||2015-02-24|
|NCI||Ding Research Highlighted by EGRP||2015-02-04|
|Nature News||Mystery Childhood Paralysis Stumps Researchers||2015-01-28|
|(e) Science News||Year in Review: Genes Linked to Tameness||2014-12-16|
|STL Today||Genome Institute Gets $25 Million Gift to Continue Its Pioneering Discoveries||2014-12-12|
|(e) Science News||Untangling the Bird Family Tree||2014-12-11|
|The Economist||The Evolution of Birds: A History of Birds in 48 Genomes||2014-12-11|
|BetaWired||A Vaccine for Cancer?||2014-11-28|
|New York Times||Our Cats, Ourselves||2014-11-24|
|St. Louis Business Journal||Startup Commercializing Wash U Prostate Cancer Research Gets $1.1 million Series A||2014-11-07|
|Eureka Alert||What's Mighty About the Mouse? For Starters, Its Massive Y Chromosome||2014-11-04|
|Genetic Engineering and Biotechnology News||Exceptional Responders - The N of 1 Paradigm||2014-10-31|
|STL Today||Researchers Dive Deep into Rare Enterovirus||2014-10-30|
|Medical XPress||Many Older People Have Mutations Linked to Leukemia, Lymphoma in Their Blood Cells||2014-10-20|
|WUSTL Newsroom||NIH Director, Sen. Roy Blunt Discuss Research Funding in Medical School Visit||2014-10-17|
|BBC News||Housefly Genome Offers Clue to Human Sickness||2014-10-14|
|Komen St. Louis||Komen Invests in the Future of Breast Cancer Research with TGI, WU||2014-10-01|
|WUSTL Newsroom||Healthy Humans Make Nice Homes for Viruses||2014-09-16|
|ABC News||Man Survives Rare Cancer Thanks to New 'Targeted' Therapy||2014-09-16|
|ABC News||Experts Weigh in on the Progress of Cancer Research||2014-09-16|
|(e) Science News||Our Microbes Are a Rich Source of Drugs||2014-09-12|
|Scientific American||Garbled DNA Might Be Good for You||2014-09-12|
|Counsel & Heal||High-Risk Leukemia Subtype Becomes More Common With Age, Genomic Analysis Reveals||2014-09-11|
|Huffington Post||For Children With the Most Common Malignant Brain Tumor, New Reason for Hope||2014-09-10|
|New Scientist||Shattering DNA May Have Let Gibbons Evolve New Species||2014-09-10|
|WUSTL Newsroom||WUSTL Scientists Among World’s Most Influential||2014-08-28|
|Biome Magazine||The ‘lnc’ Between Lung Cancer and Non-coding RNA||2014-08-18|
|OncLive||A Revolution in Classifying Cancer?||2014-08-18|
|WUSTL Newsroom||Preemies’ gut bacteria may depend more on gestational age than environment||2014-08-13|
|St. Louis American||‘Emerging Researcher’ at Harris-Stowe Wins Competition for TGI Work||2014-07-22|
|Heritage Daily||Marmoset Sequence Unveils New Information on Primate Biology and Evolution||2014-07-21|
|WUSTL Newsroom||Lung Cancer Study Hints at New Treatments||2014-07-09|
|Bio-IT World||The Hunt for a New Human Reference Genome||2014-06-30|
|Genetic Engineering and Biotechnology News||Integrating Clinical Genomics Data into Standard Medical Practice||2014-06-26|
|WUSTL Newsroom||Researchers Hone in on Way to Predict Aggressiveness of Oral Cancer||2014-06-25|
|Nature News||Therapy: This Time It's Personal||
Tailoring cancer treatment to individual and evolving tumours is the way of the future, but scientists are still hashing out the details. Dr. Elaine Mardis and colleagues from the Genome Institute and Washington University School of Medicine help a patient with atypical leukemia avoid more intensive, toxic therapy.
|The Edwardsville Intelligencer||Cassens Third Graders Introduced to DNA||
The Genome Institute researchers help local third grade students celebrate DNA Day by extracting DNA from strawberries.
|NIH Director's Blog||Different Cancers Can Share Genetic Signatures||
Using data generated through The Cancer Genome Atlas, NIH-funded researchers recently compared the genomic fingerprints of tumor samples from nearly 3,300 patients with 12 types of cancer: acute myeloid leukemia, bladder, brain (glioblastoma multiforme), breast, colon, endometrial, head and neck, kidney, lung (adenocarcinoma and squamous cell carcinoma), ovarian, and rectal.
|Wall Street Journal||Same Gene Mutations Tied to 12 Cancers||
New results from the Cancer Genome Atlas research project identify a host of genetic mutations that are common among 12 different types of cancer, reflecting the growing understanding that tumors can be defined by their underlying biology rather than their location in the body.
|St. Louis Beacon||Scientists identify mutated genes that may drive cancer development||
Scientists at the Genome Institute at Washington University School of Medicine have identified 127 significantly mutated genes that they believe drive the development of cancer.
|Bloomberg News||Deadly Cancers Driven by Relatively Few Mutations, Study Finds||
Most common tumors are driven by just two to six DNA mutations, according to a genetic analysis of 3000 tumor samples that brings scientists closer to devising a comprehensive list of all the key mutations that cause cancer or contribute to its progression.
|CNET||DNA analysis uncovers genetic errors behind 12 major cancers||
Scientists at Washington University in St. Louis say it may someday be possible to perform a single test to screen for a wide range of cancer types.
|GenomeWeb||Pan-Cancer Paper Defines Set of Significantly Mutated Cancer Genes||
The latest in a series of papers from The Cancer Genome Atlas' Pan-Cancer Initiative is highlighting more than 125 genes that appear to contribute to cancer development or progression.
|Genetic Engineering News||Surveying the Druggable Genome to Pinpoint Drug-Gene Interactions||
A drug-gene interaction database (DGIdb) has been developed that integrates existing resources to create a vast, comprehensive repository that amounts to a search engine for disease genes.
|The Scientist||2013 Top 10 Innovations Judges Set||
With the deadline to submit entries in The Scientist’s annual Top 10 Innovations competition drawing near, here we present the expert judges that will decide the winners.
|OncLive||Potential Druggable Targets Identified in Acute Myeloid Leukemia||
Acute myeloid leukemia (AML) is potentially driven by at least one genetic mutation in nearly all cases, with a complex interaction of multiple genetic events contributing to the development of the disease, according to findings published in the The New England Journal of Medicine.
|WUSTL News||In children with fever, gene profiling distinguishes bacterial from viral infections||
In children with fever but no other symptoms of illness, it is difficult to know whether a child has a viral infection that will resolve on its own or a potentially serious bacterial infection that requires antibiotics.
|Chicago Tribune||Why do some people get pimples, some not?||
The bacteria that cause acne live on everyone's skin, yet one in five people is lucky enough to develop only an occasional pimple over a lifetime. What's their secret?
|Oncology Times||Leukemia Researcher Describes 10-Year Personal Battle against Adult ALL||
Leukemia researcher Lukas Wartman, MD, has survived two relapses from adult acute lymphoblastic leukemia (ALL) with the help of genomic advances and the financial support of his colleagues at Washington University School of Medicine.
|St. Louis Public Radio||Wash U Has Four Of The World’s Top Researchers||
Four of the top twenty-one influential researchers in the world live in the St. Louis area. The researchers are from Washington University in St. Louis and all are in the field of genomics.
|The Scientist||Hottest Research of 2012 Revealed||
Genomics is the “hottest” field in scientific research for the third year in a row, according to an analysis of citation data.
|Riverfront Times||St. Louis' Richard Wilson Named "Hottest Researcher" In World, Wash. U. Scores Big||
Washington University's Richard Wilson is the hottest researcher on Planet Earth. So says Thomson Reuters, which today released its ranking of, well, "Hottest Researchers," based on some metrics that apparently do not actually involve physical appearance.
|St. Louis Business Journal||Four Washington University researchers among the ‘Hottest’ of the year||
Washington University in St. Louis is home to some of the most influential scientific researchers, according to a report by Thomson Reuters.
|St. Louis Post Dispatch||Wash U. research earns 'hottest' handle||
Seldom do "hot" and "researcher" appear in the same sentence. But Thomson Reuters has published an entire booklet dedicated to "2013 Hottest Researchers."
|Reuters||Genomics hottest field of study in 2012 - Thomson Reuters||
Genomics and particle physics - offering different perspectives on the fundamental nature of life and the cosmos - are the two hottest areas of scientific research.
|ScienceWatch (Thomson Reuters)||Who and What was Hot in Scientific Research in 2012||
Dr. Wilson is an expert in molecular genetics and large-scale DNA sequence analysis, and his laboratory at the Washington University School of Medicine is among the world's leaders in genome analysis.
|St. Louis Post Dispatch||Washington University researchers complete DNA sequencing on 200 leukemia patients||
Doctors can now view patients’ leukemia from the equivalent of a helicopter instead of an airplane with new DNA sequencing of cancer cells, an analogy described by Richard Wilson, director of Washington University’s Genome Institute.
|Cancer Research UK||US researchers unveil womb cancer and acute leukaemia genomes||
US researchers have published the intricate details of the genetic makeup of two more forms of cancer - acute myeloid leukaemia (AML) and womb (endometrial) cancer.
|International Business Times||Researchers Map Genetic Mutations In Acute Myeloid Leukemia, Endometrial Cancer||
A large consortium of scientists has created a new, detailed map of the genetic mutations that have a hand in acute myeloid leukemia, a ravenous variety of blood cancer.
|Los Angeles Times||Genomes provide clues for treating leukemia, endometrial cancers||
Efforts to sequence the human genome have revealed genetic risk for disease, and taught us about our early ancestors. Now, efforts to sequence the genomes of cancer cells -- to pinpoint the changes that occur in cancer cells' DNA when a person has the disease -- are pointing to ways to target cancer treatment.
|St. Louis Public Radio||Wash U Maps Genomes Of Two Major Cancers, Could Impact Treatment||
In separate studies both published today, researchers at Washington University mapped the genomes of two types of cancer: endometrial cancer, and acute myeloid leukemia.
|Wall Street Journal||Genomic Mutation Studies Unlock Details on Cancers||
Researchers unveiled a comprehensive look at the genetic mutations responsible for two cancers Wednesday as part of a broad government-sponsored initiative to enlist the power of genomic information to transform cancer treatment.
|New York Times||Cancers Share Gene Patterns, Studies Affirm||
Scientists have discovered that the most dangerous cancer of the uterine lining closely resembles the worst ovarian and breast cancers, providing the most telling evidence yet that cancer will increasingly be seen as a disease defined primarily by its genetic fingerprint rather than just by the organ where it originated.
|Nature News||Cancer researchers revisit 'failed' clinical trials||
By all rights, Gerald Batist’s patient should have died nine years ago. Her pancreatic cancer failed to flinch in the face of the standard arsenal — surgery, radiation, chemotherapy — and Batist, an oncologist at McGill University in Montreal, Canada, estimated that she had one year to live.
|The Scientist||Sequencing Cancer||
This month’s AACR attendees, including National Cancer Institute Director Harold Varmus, discuss new approaches to cancer research using whole genome sequencing.
|CTV News||Scientists hope turtle DNA could lead to treatment for hypothermia||
Scientists have decoded the DNA of the Western painted turtle, and hope that unravelling the mystery of the reptiles may lead to medical breakthroughs for humans.
|New Scientist||First turtle genome shows beauty more than shell-deep||
An international team of researchers have sequenced the turtle genome looking for novel genes to explain these unique physiological adaptations. However, the turtles don't rely on unique mutations for their superpowers.
|Medscape||Microbiome Opens Door to Brave New World of Therapeutics||
Microbiome researchers are on the threshold of refining a technology that is profoundly more accurate at identifying pathogens than current diagnostics. This increased accuracy should improve the likelihood that any intervention will be successful.
|Saturday Evening Post||Why We Need Germs||
We are vastly, ridiculously, hopelessly, humblingly outnumbered: For every one human cell, there are an estimated 10 single-cell microbes in us or on us, at least 100 trillion in all, nestled in our guts and in our urogenital tracts, lying on our skin and happily ensconced in our mouths and noses—entire civilizations of fungi and protozoa and (mostly) bacteria that eat and breathe, evolve and reproduce and die.
|Science||Steering Cancer Genomics Into the Fast Lane||
With her passion for DNA sequencing technology, Elaine Mardis now hopes to help cancer patients.
|St. Louis Post Dispatch||DNA research discovers 'good' acne bacteria||
Acne bacteria, the scourge of every self-conscious teen, may have met its medicinal match: more acne bacteria.
|Genetic Engineering & Biotechnology News||Next-Generation Sequencing in the Clinic||
Elaine Mardis, Ph.D., co-director of the Genome Institute at Washington University, discusses NGS and its future.
|GenomeWeb||International Team Sequences and Assembles Sea Lamprey Genome||
An international team led by investigators at the Michigan State University and the University of Kentucky have sequenced and assembled the genome of sea lamprey,
|Forbes||A Genomics Argument About Why The NIH Is Good For Business||
I wanted to find this for yesterday’s post, but didn’t get to it until today: A quote from Elaine Mardis, the Washington University in St.Louis DNA sequencing expert, about how cuts to NIH funding are hurting genomics companies like Illumina, Life Technologies, and Pacific Biosciences, even though they represent one of the few U.S. industry’s making something of value.
|Clinical Oncology News||Breakthrough Study Catalogs Breast Cancer Types||
In a finding that is expected to revolutionize future approaches to the treatment of breast cancer, researchers have confirmed the presence of four distinct subtypes of breast cancer, each with a unique heterogeneous mix of genetic and molecular abnormalities.
|Outlook||Smoking and genetics: Big impacts on smokers' genes||
Lung cancer patients with a history of smoking have 10 times more genetic mutations in their tumors than those with the disease who have never smoked, according to a new study from Washington University School of Medicine.
|Med City News||Four barriers that must fall before the personalized medicine revolution can start||
Just as Moore’s law transformed computing – and, as a result, all aspects of our professional and personal lives — so, too, will the interpretation of the human genome transform medicine. We are moving from the inefficient and experimental medicine of today towards the data-driven medicine of tomorrow. Soon, diagnosis, prognosis, treatment, and most importantly, prevention will be tailored to individuals’ genetic and phenotypic information.
|The personalized medicine revolution is almost here||
We are at the dawn of a new age of personalized medicine. Just as Moore’s law transformed computing – and, as a result, all aspects of our professional and personal lives — so, too, will the interpretation of the human genome transform medicine.
|St. Louis Business Journal||Even 'junk' DNA holds clues about cancer, WashU researchers find||
Whole-genome sequencing and analysis is the bleeding edge of medical research, and Washington University is one of the leaders in the field. And now researchers there think they have found more clues about cancer genes in the part of human DNA previously thought of as 'junk.'
|The Scientist||Non-coding Mutations May Drive Cancer||
Mutations in the regulatory, or non-coding, regions of the telomerase reverse transcriptase (TERT) gene—a cancer-associated gene that encodes a component of telomerase, an enzyme known to help protect the ends of chromosomes and support cell longevity—may be at the root of most melanomas, according to two papers published today (January 24) in Science.
|New York Times||New Mutations Discovered in Melanomas||
In a leap forward in understanding the basic science of one of the most lethal cancers, two groups of researchers have found mutations in most melanomas that are unlike any they have seen before in cancer. The changes are in regions that control genes, not in the genes themselves. The mutations are exactly the type caused by exposure to ultraviolet light, indicating they might be among the first DNA changes in a cell’s path to melanoma.
|Men's Health New Zealand||The Dirty Secret of Perfect Health||
In mid-November 2010, Alex O. wondered for the first time if he might be dying.
For six weeks, the 27-year-old had been suffering from a digestive disease as horrific as it was mysterious. Shortly after breaking up with his girlfriend in late September that year, he’d started experiencing bouts of diarrhoea, which he initially thought might be due to the stress month, however, his diarrhoea hadn’t improved and was now flecked with blood. Stabs of gut pain had begun to wake him up at night. “The persistence of the diarrhoea,” he recalls, “kind of told me it wasn’t due to my mental landscape.”
|St. Louis Magazine||Power List 2012: 100 People Who Are Shaping St. Louis Today||
In 2003, when the Human Genome Project deciphered the Rosetta stone of our own genetic makeup, the scientists at Wash. U’s Genome Institute contributed 25 percent of the final sequence.
|Outlook||Genetic portraits: A global search for the underlying roots of disease||
By decoding the genomes of more than 1,000 people whose homelands stretch from Africa and Asia to Europe and the Americas, scientists have compiled the largest and most detailed catalog yet of human genetic variation.
|Medical News Today||DNA Of Gut Microbes Has Unique Fingerprint||
New research suggests the DNA of the vast collection of microbes in the gut has a unique figerprint that can identify individuals in the same way as human DNA.
|WUSTL News||Existing drugs may help more with breast cancer||
More patients can benefit from highly effective breast cancer drugs that are already available, according to DNA sequencing studies by researchers at Washington University School of Medicine in St. Louis and other institutions.
|GenomeWeb||Malachi and Obi Griffith: Scientific Curiosity, Personal Drive||
For twin brothers Malachi and Obi Griffith, their drive toward understanding the cancer genome is more than just scientific curiosity, it's personal. A few weeks before they graduated from high school, their mother died from breast cancer.
|St Louis Business Journal||Genome Institute adopts visual map technology for genome sequencing||
Researchers at the Genome Institute at Washington University are using a new genome sequencing technology that provides a high resolution, complete visual map of a whole genome and individual chromosomes.
|BioOptics World||DNA sequencing technologies: The next generation and beyond||
There are many commonalities—and a few critical differences—among second- and third-generation sequencers. This article reveals the inner workings of each commercially available system, including specialized optical components, and explores the future of DNA sequencing.
|UPI||Global genomes are medical road map||
Genomes of people whose homelands stretch from Africa and Asia to Europe and the Americas will help researchers find genetic roots of diseases, researchers say.
|St Louis Public Radio||International Consortium Sequences 1000 Human Genomes||
An international consortium of researchers has sequenced the genomes of more than 1000 people, creating the largest catalog yet of human genetic variation.
Richard Wilson directs the Washington University Genome Institute, one of four major research institutions involved in the 1000 Genomes Project.
|OncLive||Putting the Genome to Work in Breast Cancer||
Although breast cancer is among the best-characterized tumor types, continuing efforts to refine the sequencing of the human genome are opening the door to a new treatment paradigm in which oncologists will have swift access to a wealth of information that will enable more personalized therapy for patients at earlier stages of disease.
|St Louis American||Genome research finds some deadly forms of breast cancer genetically similar to ovarian||
A striking revelation in the most comprehensive analysis of breast cancer to date finds that one of the most deadly forms – the triple negative – which disproportionately affects African American and younger women – is genetically more similar to ovarian cancer tumors than breast cancers.
|GenomeWeb||Many, Many Microbiomes||
It's one thing to know that they are everywhere: teeming masses of microbes covering computer keys, eking their way into plant roots, coating the human body
|Genetic Engineering & Biotechnology News||Aggressive Breast Cancer May Respond to Ovarian Cancer Treatment||
A major breast cancer analysis project has catalogued the spectrum of mutations that underpin the four basic categories of the disease, and also found that one of the most aggressive forms of breast tumor shares more features at the mutational level with high-grade serous ovarian tumors than with other subtypes of breast cancer. The data, published in Nature, represents the most comprehensive molecular blueprint of breast cancer generated to date, and could help researchers design and develop more effective drugs and combination treatment regimens that target each subtype of disease according to its molecular background.
|Los Angeles Times||Genetics to determine cancer treatments||
The war on cancer is poised to enter a new phase that promises more precise treatments, fewer side effects and, most of all, more survivors.
|Nature News||Studies offer ‘panoramic view’ of lung cancer||
Lung cancer causes more deaths than any other form of cancer. About 1.6 million people worldwide are diagnosed with the disease each year, with fewer than 20% still alive five years later.
|St Louis Public Radio||New study suggests the key to treating cancer may lie in its genetics (St. Louis Public Radio)||
New genetic research on lung cancer may help open the door to more targeted cancer treatments.
|OncLive||Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine: Leading the Way in Cancer Genomics||
An international leader in cancer treatment, research, prevention, education, and community outreach, the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, Missouri, is the only cancer center in the state (and within a 240-mile radius of St. Louis) to be designated a Comprehensive Cancer Center by the National Cancer Institute, and to serve as a member of the National Comprehensive Cancer Network.
|St Louis Post Dispatch||New DNA research may offer clues into disease||
A colossal international effort has yielded the first comprehensive look at how our DNA works, an encyclopedia of information that will rewrite the textbooks and offer new insights into the biology of disease.
|Fox News||Cancer drug helps patient despite faltering in trials||
A cancer drug that isn't passing muster in clinical trials may still be the answer for some patients, a new study says.
|Telegraph||Killing cancer: stories from the cutting edge of science||
Every two minutes, someone in this country is diagnosed with it – and more than one in three British men and women will develop it in their lifetime.
|CBS This Morning Video||Cancer doctor becomes cancer patient||
Dr. Lukas Wartman was diagnosed with the very cancer he'd devoted his life to studying -- a disease with no known cure. Then, some of his fellow doctors at Washington University School of Medicine, in St. Louis, convinced him to try something that had never been done before, making Wartman a very important patient. He talks to Charlie Rose, along with his colleague, oncologist Dr. John DiPersio.
|St Louis Post Dispatch||College students get chance to work at WU genome lab||
Edgar Campbell, 22, wasn't thinking of a career in science while in high school, or even in college. He took science classes and watched the Discovery Channel, he said. "But I never thought it would be my future."
|Charlie Rose Show Video||Frontiers in Cancer Research||
Frontiers in Cancer Research with Gina Kolata, The New York Times; Dr. John DiPersio, MD, PhD, Washington University School of Medicine; and Dr. Lukas Wartman, MD, Washington University School of Medicine.
|New York Times||In Treatment for Leukemia, Glimpses of the Future (New York Times)||
Genetics researchers at Washington University, one of the world's leading centers for work on the human genome, were devastated. Dr. Lukas Wartman, a young, talented and beloved colleague, had the very cancer he had devoted his career to studying. He was deteriorating fast. No known treatment could save him. And no one, to their knowledge, had ever investigated the complete genetic makeup of a cancer like his.
|New York Times Video||Second Chance||
Lukas Wartman, a leukemia doctor and researcher, developed the disease himself. As he faced death, his colleagues sequenced his cancer genome. The result was a totally unexpected treatment.
|New York Times||Tending the Body's Microbial Garden (New York Times)||
For a century, doctors have waged war against bacteria, using antibiotics as their weapons. But that relationship is changing as scientists become more familiar with the 100 trillion microbes that call us home — collectively known as the microbiome.
|Economist||Genetic mutations predict which cancers will respond to treatment||
The International Cancer Genome Consortium, an alliance of laboratories that is trying to produce a definitive list of the genetic mutations that cause cancer, is accumulating data at an astonishing rate.
|Los Angeles Times||Scientists map genome of the bonobo, a key human ancestor||
Researchers have assembled the complete genome of the bonobo, an African ape that is one of humans' closest relatives.
|TIME||The Good Bugs: How the Germs in Your Body Keep You Healthy||
The human genome is made up of about 23,000 genes. That’s a fairly impressive figure. Until you consider this: the number of non-human genes each of us carries around — from the bacteria, viruses and other pathogens living in and on us — totals 8 million.
|NPR||Finally, A Map Of All The Microbes On Your Body||
Scientists Wednesday unveiled the first catalog of the bacteria, viruses and other microorganisms that populate every nook and cranny of the human body.
|Reuters||U.S. scientists map genes of microbes in healthy people||
U.S. scientists have analyzed 5,000 samples taken from swabs and scrapings of 250 volunteers and developed the first genetic reference map of nearly all of the microbes inhabiting healthy humans.
|Technology Review||Researchers Catalog Your Microbial Zoo||
A large National Institutes of Health initiative has published the most comprehensive catalog yet of the microörganisms that live on and in the human body. By characterizing the ecology of the bacteria, viruses, fungi, and other microbes that inhabit healthy people, the researchers have established a baseline for the normal "human microbiome." The work could accelerate research on development, obesity, infectious diseases, and more.
|New Scientist||Milk fats clue to inflammatory bowel disease||
Concentrated milk fats, a common ingredient of processed foods and confectionary, trigger blooms of otherwise rare gut bacteria in mice that may contribute to inflammatory gut diseases.
|St. Louis Business Journal||Komen gives $5.4 million to Siteman for breast cancer research||
Susan G. Komen for the Cure has awarded more than $5 million in new grants to Washington University scientists at the Alvin J. Siteman Cancer Center to develop new breast cancer treatments, university officials said.
|GenomeWeb||WUSTL, ICR to Use $4M Komen Grant to Develop Breast Cancer Dx, Screen Treatments||
Scientists at Washington University in St. Louis and the Institute of Cancer Research in London plan to use a $4 million grant from the Susan G. Komen for the Cure foundation to identify which breast cancer patients are most likely to experience recurrence and to identify new drug treatments aimed at those women.
|NYTimes||A Geneticist's Research Turns Personal||
Human genome sequencing is already helping researchers find new treatments for illness. Now an unusual case study suggests that the benefits of sequencing may be enhanced in combination with detailed blood tests.
|GenomeWeb||NHGRI Allocates $4M for Informatics Development for Sequence Data Analysis||
The National Human Genome Research Institute has awarded about $4 million to six research teams to develop bioinformatics software for analyzing sequence data.
|TIME||Decoding Cancer: Scientists Release 520 Tumor Genomes from Pediatric Patients||
Could the answer to cancer lie within our own DNA? Childhood cancer experts are hoping that at least some of what drives pediatric cancers can be gleaned from the genomes of patients and their tumors.
|BBC News||Scientists unveil extensive child cancer research data||
US scientists have released the world's largest collection of genetic data on childhood cancers in a bid to speed up treatment discoveries. The US Pediatric Cancer Genome Project has mapped the entire genome - all the DNA - of 260 young cancer patients.
|Reuters||Leukemia gene mutations linked to survival odds||
Advances in genetic profiling are paving the way for more precise, and effective, treatment of the aggressive bone marrow cancer known as acute mylogenous leukemia, or AML, according to new research.
|BBC News||Gorilla genome could hold key to the human condition||
Researchers in Cambridge have deciphered the genetic code of the gorilla - the last of the Great Ape genuses to be sequenced.
|New York Times||Company Unveils DNA Sequencing Device Meant to Be Portable, Disposable and Cheap||
DNA sequencing is becoming both faster and cheaper. Now, it is also becoming tinier.
A British company said on Friday that by the end of the year it would begin selling a disposable gene sequencing device that is the size of a USB memory stick and plugs into a laptop computer to deliver its results.
|Cancer Research UK||US scientists show how immune system 'prunes' tumours||
Laboratory research by US scientists has shown for the first time how the body's immune system shapes how a tumour grows.
|LA Times||Genomes offer clues to treating childhood cancers||
On Tuesday, two biotech companies announced that it would soon be possible to sequence the human genome -- each individual's complete DNA blueprint -- in about a day for around $1,000.
|US News and World Report||DNA Damage From Chemo May Help Spur Leukemia's Return||
The chemotherapy used to treat a form of adult leukemia sets a trap that can result in the return of the disease within years, a new study suggests.
|Fox News||Chemotherapy treatment might induce leukemia relapse||
Chemotherapy drugs, the first line of defense for a common form of adult leukemia, could actually be contributing to the disease’s rate of relapse in patients.
|The Scientist||High-Tech Choir Master||
Elaine Mardis was in the right place at the right time. During her senior year as a zoology major at Oklahoma University, Mardis found herself at loose ends. “It wasn’t readily apparent to me what to do next,” she says. “Then I took a biochemistry class—and the instructor was one Bruce A. Roe.
|St. Louis Post-Dispatch||Work begun on Wash U data center expansion||
Construction is underway on a $12.5 million project to double the size of the genetics data center at the Washington University School of Medicine. Clayco Inc., a design/build firm, began construction last month. Completion is scheduled for next May.
|St. Louis Post-Dispatch||Work on cells targets tumors||
Imagine two women sitting in an oncologist's office. Both have been diagnosed with a type of breast cancer called hormone-receptor positive, and both will receive the same chemotherapy drug.
|WUSTL News||Key genetic error found in family of blood cancers||
Scientists have uncovered a critical genetic mutation in some patients with myelodysplastic syndromes — a group of blood cancers that can progress to a fatal form of leukemia.
|Nature News||Funds dedicated to personalized genetics||
The US National Institutes of Health has earmarked nearly half a billion dollars for a plan that it hopes will usher in an era of diagnoses and treatments based on genome sequencing.
|GenomeWeb - Registration Required||NHGRI Unveils New-Look Genome Sequencing Program; Plans $416M in Funding||
The National Human Genome Research Institute today unveiled an updated model of its flagship genome sequencing program that represents a partial shift away from large-scale sequencing and toward applied genomics and informatics projects.
|GenomeWeb - Registration Required||Wash U's Informatics Group Releases Toolset for Genomic Analysis, Data Management||
The informatics group at the Genome Institute at Washington University School of Medicine has released an integrated analysis and information-management system called the Genome Modeling System.
|New York Times||DNA Sequencing Caught in Deluge of Data||
BGI, based in China, is the world’s largest genomics research institute, with 167 DNA sequencers producing the equivalent of 2,000 human genomes a day.
|WUSTL News||Washington People: Matthew J. Ellis||
Ellis decodes the mysteries of breast cancer in search of better treatments. When Matthew Ellis was 10 years old, growing up in Kibworth Beauchamp, England, he told his religious studies teacher he wanted to be a doctor.
|St. Louis Post-Dispatch||Genome Institute at Washington U. works on project to help target cancer||
Written along the 3 billion letters that make up our genetic code are clues to the origins of cancer. Researchers at the Genome Institute at Washington University have been deciphering those clues by "reading" the letters of the genetic code (A's, C's, G's and T's) so they can figure out what turns normal cells cancerous.
|Nature||Human genetics: Genomes on prescription||
The first thing Debbie Jorde noticed about her newborn daughter was that her arms were bent at unnatural angles. She had other problems, too: a cleft palate, eight fingers, eight toes and no lower eyelids.
|GenomeWeb - Registration Required||Sequencing Uncovers Antibiotic Resistance-Related Mutations in Superbug||
By sequencing the genomes of bacteria from two clinical samples from the same patient, researchers have identified mutations conferring resistance to the antibiotic daptomycin in an Enterococcus faecalis that was already resistant to vancomycin.
|CBS News||Antibiotic overuse may be bad for body's good bacteria||
Antibiotic overuse doesn't just lead to drug-resistant superbugs, it may also permanently wipe out the body's good bacteria. Good bacteria in the gut help people in many ways, including helping make vitamins and boosting immunity.
|BBC News||Newly sequenced DNA - how the kangaroo got its bounce||
An international team of scientists, writing in the Biomed Central journal, Genome Biology, say they have even indentified a gene responsible for the kangaroo's hop. The group focussed on a small species of kangaroo that inhabits islands off Australia's south and western coasts.
|NCI Cancer Bulletin||Whole-Genome Sequencing for Cancer Enters the Clinic||
Launched in 1990 and formally completed in 2003, the Human Genome Project took 10 years to produce the first draft sequence of an entire human genome. Today, a draft sequence of an entire human genome can be produced in about 10 days, according to Dr. Elaine Mardis, co-director and director of technology development at the Genome Institute.
|Science Now||Unveiling the Genetic Landscape of Ovarian Cancer||
Ovarian cancer is difficult to detect early, and fewer than half of the 22,000 women diagnosed annually in the United States will live more than 5 years.
|US News & World Report||Gene 'Map' of Ovarian Cancer Yields New Clues to Treatment||
In the largest such study of any tumor type to date, scientists say they've gleaned an in-depth look at genes that may help drive aggressive ovarian cancer.
|WUSTL News||Detailed picture of ovarian cancer emerges||
Scientists have completed the largest analysis to date of the genetic mutations underlying ovarian cancer. The research was conducted by scientists at Washington University’s Genome Institute and elsewhere as part of The Cancer Genome Atlas (TCGA) project.
|GenomeWeb - Registration Required||Renaming its Genome Center, Wash U Expands Focus to Clinical Applications of Sequencing||
Washington University has renamed its Genome Center the Washington University Genome Institute, marking its commitment to the clinical applications of sequencing.
|WUSTL News||Federal research funding to Washington University provides economic boost to region||
Federal investment in biomedical research is a major driver of jobs and economic activity. Two new reports highlight the ripple effects of this investment.
|Chemical & Engineering News (Registration Required)||The Next Generation In Genome Sequencing||
Every now and then, a headline says it all. An article last fall in Genome Medicine, for example, carried this one: "The $1,000 genome, the $100,000 analysis?"
|Science News||DNA flaws can stack up as cancer grows||
As a man's cells grew cancerous, a wide range of mutations gradually emerged too, a new gene sequencing study finds. The results provide a deep understanding of the genetic changes that allowed an aggressive form of leukemia to set in and take hold in one patient, Elaine Mardis of Washington University in St. Louis said in a March 28 presentation at the annual conference on Research in Computational Molecular Biology.
|St. Louis Post-Dispatch||Study here targets guts of premature babies||
About six months ago, Dr. Barbara Warner got a call in the middle of the night — the kind that she has come to dread. Warner, a neonatologist, had been caring for a boy born at 26-weeks gestation. Until that night, the baby had been growing gradually stronger. He'd survived the lung problems typical of premature babies that age, was off the ventilator, and was consuming breast milk provided by his mother.
|Voice of America||Human Genome Sequencing Helps Doctors Determine Treatment||
Sequencing the human genome - making a detailed map of all of a person's genes - is less than a decade old. The technology brings with it the promise of personalized medicine.
|GenomeWeb - Registration Required||Cancer Studies Highlight Clinical Potential of Genome Sequencing||
A pair of cancer genome sequencing studies appearing online in the Journal of the American Medical Association last night are illustrating the potential of using sequencing and analyses in a clinical setting.
|WebMD||Whole-Genome Testing Could Become Diagnosis Tool||
Less than a decade after the first human genome was sequenced at a cost of hundreds of millions of dollars, whole-genome sequencing is poised to become a useful and affordable diagnostic tool, experts say.
|Technology Review||Cancer Genomics||
In the fall of 2006, a new machine arrived at what's now known as the Genome Institute at Washington University in St. Louis. It was capable of reading DNA a thousand times as quickly as the facility's earlier machines, and at far less cost. Elaine Mardis, the center's codirector, immediately began using it to sequence cancer tissues, scouring their DNA for mutations.
|AFP News Agency||Faster, cheaper genome advances propel cancer care||
Genome-sequencing is getting cheaper and faster, and can eliminate the guesswork in treating cancer by offering personalized clues on how to best attack tumors, US doctors said on Tuesday.
|HealthDay||Genome Scans May Reveal Life-Saving Alternatives for Cancer Patients||
A 39-year-old woman is referred to Washington University's Siteman Cancer Center in St. Louis with suspected acute myeloid leukemia (AML), a cancer that can be treated relatively simply with medication, or not so simply with a high-risk stem cell transplant, depending on the tumor subtype.
|Time Magazine||Decoding Cancer||
Treating cancer is a bit like shooting in the dark. Sometimes it works. Sometimes it doesn't. There's no way to predict. That's because while scientists have some crude ideas about how to disable cancer cells, the inner workings of cancer are a mystery for the most part.
|Science NOW||Double the Genes, Double the Flora||
From wildflower meadows to redwood forests to alpine bogs, the diversity of seed plants rings out as one of evolution's great achievements. An analysis of the genes of more than a dozen plant species has now shown that this variety was jump-started 320 million years ago and received a further kick 120 million years later.
|KTVI-FOX2now||Washington University Decodes Breast Cancer Tumor DNA||
If information is power then Washington University may have found another weapon in the fight against breast cancer. Washington University successfully decoded the DNA of tumor cells taken from 50 breast cancer patients.
|Nature Medicine||Sequencing reveals suite of commensal and pathogenic viruses||
After coming to realize that symbiotic bacteria play a large part in running our bodies, scientists are slowly beginning to appreciate the importance of our viral communities, too. As researchers discussed here last month at the International Human Microbiome Congress, new sequencing techniques are revealing that these viruses - collectively called the 'virome' - often differ significantly between healthy and diseased individuals.
|Wall Street Journal||Researchers Unveil Breast Cancer Genome Of 50 Patients||
Researchers unveiled the genome of 50 breast cancers Sunday which could lead to a better understanding of why existing treatments don't always work and provide new targets for drug developers.
|Nature News||Fifty genome sequences reveal breast cancer's complexity||
The deeper researchers dive into the genetics of breast cancer, the more complicated their discoveries. And the latest, and deepest, dive is no exception.
|WUSTL News||DNA of 50 breast cancer patients decoded||
In the single largest cancer genomics investigation reported to date, scientists have sequenced the whole genomes of tumors from 50 breast cancer patients and compared them to the matched DNA of the same patients' healthy cells. This comparison allowed researchers to find mutations that only occurred in the cancer cells.
|US News and World Report||Most Breast Tumors Have Unique Genetic 'Fingerprint,' Study Finds||
Researchers who sequenced the entire genomes of tumors from 50 breast cancer patients identified more than 1,700 mutations, most of which were unique to individual patients.
|Science Magazine||Going Viral: Exploring the Role Of Viruses in Our Bodies||
In the past decade, scientists have come to appreciate the vast bacterial world inside the human body. They have learned that it plays a role in regulating the energy we take in from food, primes the immune system, and performs a variety of other functions that help maintain our health. Now, researchers are gaining similar respect for the viruses we carry around.
|UPI||Study: Mouse genome has human cancer clue||
U.S. researchers say sequencing the genome of a mouse with cancer turned up mutations that also drive cancers in humans, a step in understanding the disease.
|GenomeWeb - Registration Required||Mouse Cancer Genome Highlights Mutations Relevant to Human Disease||
Researchers from Washington University School of Medicine are complementing their ongoing human cancer genome sequencing studies by sequencing tumors from mouse models of cancer.
|WUSTL News||Mouse cancer genome unveils genetic errors in human cancers||
Scientists who pioneered sequencing the genomes of cancer patients to find novel genetic changes at the root of the disease now have turned their attention to a laboratory workhorse - a mouse.
|Reuters||The Hottest Research of 2010||
The time has rolled around yet again for Science Watch to take its annual look back at the hottest of recent research. The tab below are the researchers who, according to citations recorded during 2010, fielded the highest number of Hot Papers published over the preceding two years.
|GenomeWeb - Registration Required||Researchers Sequence Genome of Trichinosis Parasite||
In a paper appearing online yesterday in Nature Genetics, a Washington University-led research team reported that it has sequenced the genome of Trichinella spiralis, the parasitic nematode behind most cases of the food borne illness trichinellosis, also known as trichinosis.
|WUSTL News||Trichinosis parasite gets DNA decoded||
Scientists have decoded the DNA of the parasitic worm that causes trichinosis, a disease linked to eating raw or undercooked pork or carnivorous wild game animals, such as bear and walrus.
|GenomeWeb - Registration Required||Researchers Sequence Leaf-cutter Ant Genome||
By sequencing the genome and transcriptome of the leaf-cutter ant Atta cephalotes, researchers are learning about the genetic features contributing to the ant's obligate symbiotic relationship with the fungus it farms.
|Daily Mail||How humans are 97% the same as orangutans: New research shows how DNA matches||
Orangutans may be more closely related to humans than scientists previously thought, a new genetic study has shown.
|BBC News||Orangutan genome 'evolved slowly'||
Scientists have released a draft sequence of the orangutan genome, revealing intriguing clues to the evolution of great apes and humans.
|St. Louis Public Radio||Researchers sequence genome of endangered orangutans||
An international team of researchers has sequenced the genomes of two species of orangutan. Lead researcher Devin Locke of the Genome Center at Washington University said a primary motivation for studying the genes of orangutans is their close evolutionary relationship to humans.
|MSNBC||Orangutan's genetic instructions for life unlocked||
Susie, a female Sumatran orangutan from a Texas zoo - along with a few of her kin in the wild - has been decoded, her genetic instructions for life laid out for scientists to inspect, an international team of researchers announced Wednesday.
|New Scientist||Tiny orang-utan populations are surprisingly diverse||
If the two surviving species of orang-utan ever find their way off the endangered list, they might have their genes to thank. One of the most detailed analyses of the primate's genome to date has revealed its tiny populations are surprisingly diverse at the genetic level, which increases the likelihood that the ginger apes could bounce back from the brink.
|WUSTL News||Orangutan DNA more diverse than human's, remarkably stable through the ages||
Among great apes, orangutans are humans’ most distant cousins. These tree dwellers sport a coat of fine reddish hair and have long been endangered in their native habitats in the rainforests of Sumatra and Borneo in Southeast Asia.
|Nature News||Orang-utans join the genome gang||
Orang-utans can now be added to the list of species that have had their genomes sequenced, offering conservationists a wealth of data in their efforts to save the endangered great ape.
|Science Now||Orangutan Genome Full of Surprises||
The orangutan, the most sedentary of the great apes, has unusually stable DNA, too. Researchers have just completed the sequencing of the entire genome of our orange-haired relative, and they have found to their surprise that its DNA has changed much less dramatically over time than has that of humans or chimpanzees.
|Reuters||Gene study shows way to help save orangutans||
Orangutans are notoriously slow and gentle, and a study of their DNA shows they have evolved in a similar way, researchers reported on Wednesday.
|Genome Technology - Registration Required||Makedonka Mitreva: Genomics to Power Study of Neglected Diseases||
It was a fascination with the destructive power of microscopic pathogens that brought Makedonka Mitreva to study helmenthic parasites. Parasitic nematodes, she says, cause about half of the world's neglected tropical diseases and can lead to blindness and affect child development, in addition to wreaking havoc on crops and livestock.
|Time.com||A Step Toward Personalized Care of Leukemia Patients||
Researchers have discovered gene mutations in patients with acute myeloid leukemia (AML) that may help doctors determine which treatments will work best for which patients early on. Patients with AML, a cancer of the blood, have a 20% five-year survival rate overall, but the new discoveries may increase the chances of survival for certain patients.
|WUSTL News||Mutations in single gene predict poor outcomes in adult leukemia||
Decoding the DNA of a woman who died of acute myeloid leukemia (AML) has led researchers at Washington University School of Medicine in St. Louis to a gene that they found to be commonly altered in many patients who died quickly of the disease.
|NIH News||Researchers discover key mutation in acute myeloid leukemia||
Researchers have discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia (AML), an aggressive blood cancer that kills 9,000 Americans annually. The scientists report their results in the Nov. 11, 2010, online issue of The New England Journal of Medicine.
|BusinessWeek||Gene Mutations Seem to Make a Leukemia More Deadly||
Researchers have pinpointed a gene with multiple mutations that seems to separate people who die quickly from acute myeloid leukemia (AML) from those who do not.
|WUSTL News||Thomas visits The Genome Center||
Actress Marlo Thomas talks with Richard Wilson, PhD, director of The Genome Center, Oct. 28 in The Genome Center at the School of Medicine. The Genome Center is partnering with St. Jude Children’s Research Hospital in Memphis on the Pediatric Cancer Genome Project, the largest research project to date aimed at understanding the genetic origins of pediatric cancers.
|St. Louis Beacon||Genome research institute director is part of St. Louis' first family of science||
Maurice Green, a prominent Saint Louis University virologist, went out of his way not to push his children toward medical careers. But it didn't take long for him to realize that the younger generation had inherited his interest in science.
|Genetic Engineering & Biotechnology News||Pilot Phase of 1000 Genomes Project Identifies 8 Million New Genetic Variants||
Researchers involved in the international 1000 Genomes Project have published data from the three studies that constituted the pilot phase of the four-year initiative. The results, from the sequencing of 800 individuals, describe the location, allele frequency, and local haplotype structure of approximately 15 million SNPs, 1 million short insertions and deletions, and 20,000 structural variants.
|Telegraph||Scientists from 1,000 Genomes Project have identified 95 per cent of genetic variations||
Early work by the 1,000 Genomes Project, which aims to collect data from 2,500 people from across the world, has found 16 million previously unknown variations in DNA.
|GenomeWeb - Registration Required||Going 'Beyond the Genome'||
BioMed Central's Beyond the Genome conference in Boston this week — which was held in conjunction with Genome Biology's 10th anniversary — showcased the work of several researchers whose ideas go beyond just sequencing.
|Nature News||Poisonous Platypuses Confirm Convergent Evolution||
Don't be fooled by the playful-looking duck's bill — platypuses deliver a venom containing more than 80 different toxins. The finding, from an analysis of the genes encoding the dangerous mixture, also reveals the striking similarities between the poisons of different animals.
|Bio-IT World||Re-Defining Storage for the Next Generation||
“There are no vendors that have their finger on the pulse of the problem. I can tell you in no uncertain terms that that is the case.” David Dooling, assistant director of informatics at The Genome Center at Washington University is not mincing words. But he’s not totally throwing storage vendors under the bus either.
|Technology Review||Treating Cancer Based on Its Genome||
Just two years ago, scientists published the sequence of the first cancer genome, detailing the constellation of genetic mutations that likely enabled tumor cells to grow out of control. Now a handful of scientists and physicians are starting to use data from this "whole genome analysis" to help them choose the best drugs for their patients.
|Telegraph||Human Microbiome Project: a map of every bacterium in the body||
Scientists suspect that some patients fail to respond to conventional treatment for intestinal infections because they are lacking certain bacteria, which have a protective role, found in the normally functioning gut.
|New York Times||How Microbes Defend and Define Us||
In 2008, Dr. Khoruts, a gastroenterologist at the University of Minnesota, took on a patient suffering from a vicious gut infection of Clostridium difficile.
|USA Today||The human genome: Big advances, many questions||
Every Wednesday at 3:15 p.m., a few dozen Stanford University medical students turn their backs on the sun, gather in a high-tech classroom and flip open their laptops.
|Nature Methods||Next-generation sequencing: adjusting to data overload||
To keep pace with accelerating sequencing machines, genomics researchers clean house and move toward the cloud.
|GenomeWeb - Registration Required||Weinstock Provides Human Microbiome Project Update at ASM||
At the American Society for Microbiology meeting, Washington University's George Weinstock outlined progress being made on the Human Microbiome Project.
|WUSTL News||Scientists decode DNA of microbes from humans||
As part of the Human Microbiome Project (HMP), scientists at Washington University School of Medicine in St. Louis and their colleagues have decoded the genomes of 178 microbes from the human body.
|GenomeWeb - Registration Required||Washington University Team Sequences AML Relapse Tumor||
By sequencing the genome of a relapse tumor isolated from an individual with acute myeloid leukemia and comparing it to primary tumor and normal skin genomes from the same individual, researchers from Washington University have identified relapse-specific mutations that offer clues to the cancer's evolution.
|WUSTL News||Three faculty named to American Academy of Arts and Sciences||
Three Washington University School of Medicine professors have been elected fellows of the American Academy of Arts and Sciences. The new fellows are Susan K. Dutcher, PhD, professor of genetics and of cell biology and physiology; Timothy J. Ley, MD, the Alan and Edith Wolff Professor of Medicine, professor of genetics, director of the Stem Cell Biology Section of the Division of Oncology, and associate director for cancer genomics at the Genome Center; and Robert D. Schreiber, PhD, Alumni Endowed Professor of Pathology and Immunology, professor of molecular microbiology and leader of the Tumor Immunology Program at the Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and the School of Medicine.
|National Cancer Institute||Genome Study of Aggressive Breast Cancer Yields Clues to Metastasis||
To study how cancer cells change as the disease progresses, researchers have carried out a genome analysis of four DNA samples from a woman with breast cancer whose disease spread to her brain. In addition to the primary breast and metastatic brain tumors, the researchers used the patient’s normal blood cells and a tumor grown in a mouse from a sample of the original tumor (a xenograft).
|News24||Killer cancer had 50 mutations||
Washington - Breast tumours that killed an American woman with so-called "triple negative" cancer had 50 separate mutations, including 20 that helped them spread, researchers reported on Wednesday. New techniques for sequencing the entire genetic map of cells helped the team figure out the changes needed for cancer to spread and kill. The findings may lead to new tests and new treatments for cancer, they reported in the journal Nature.
|KWMU News||Tumor genomes may reveal how cancer spreads||
Scientists have mapped the genome of a 44-year-old African American woman with a highly lethal form of breast cancer, known as a "basal" subtype. The researchers compared the patient's healthy DNA to the DNA sequences in her original breast tumor and in a subsequent fatal tumor that developed in her brain.
|BusinessWeek News||Genome sequencing reveals how breast cancer spreads||
Genetic analysis of a woman with breast cancer has yielded important information about an extremely dangerous type of breast cancer that largely affects blacks and younger women, say U.S. researchers. By comparing three genomes -- the genome of a 44-year-old black woman who had "triple negative" breast cancer and the genomes of her breast tumor and a metastatic tumor that developed in her brain -- the scientists identified 20 genetic changes in a subset of breast tumor cells that probably played a role in the spread of the cancer that led to her death within a few months.
|KMOV News||Major breakthrough in breast cancer research announced at Wash. U||
A major breakthrough in cancer research announced at Washington University. Scientists at Wash U. are using powerful DNA sequencing technology to decode the genomes of a breast cancer patient. A genome holds all of our hereditary information and reveals clues to curing cancer. The scientists' findings were published in the medical journal, "nature."
|Technology Review||Genetic Clues to Cancer's Spread||
Scientists have identified genetic clues to how a tumor spreads throughout the body. Understanding the genetic aberrations that enable the metastasis of cancers could help scientists design better prognostic tests and more effective treatments.
|WUSTL News||Decoding tumor genomes reveals clues to spread of deadly breast cancer that affects younger women, African-Americans||
Using powerful DNA sequencing technology to decode the genomes of cancer patients, scientists at Washington University School of Medicine in St. Louis are getting an unprecedented look at the genetic basis of a highly lethal breast cancer that disproportionately affects younger women and those who are African-American.
|New York Times||From a Songbird, New Insights Into the Brain||
Researchers have gained new insights into the brain by decoding the genome of the zebra finch, a songbird whose males learn a single love song from their fathers that they repeat through life.
|ABC News||Persons of the Week: Washington University Bird Researchers||
The secret to understanding how humans learned to speak may come from an unlikely place — the love songs of the Australian Zebra Finch. This week, scientists at the Washington University School of Medicine announced that after 20 years of work, they have finally mapped the genome of the small bird species that learns love songs the same way a human learns words.
|BBC News||Blueprint of the songbird genome||
Scientists have created a "blueprint" of the genome of a songbird. The advance, described in the journal Nature, could reveal some of the evolutionary secrets of vocal learning in animals, including humans.
|NPR||Songbird DNA May Offer Clues To Human Speech||
Zebra finches have complex songs that are learned throughout adolescence. Scientists who recently sequenced the finch's genome say that their research may lead to a clearer understanding of human speech-related disorders like those caused by autism, strokes and Parkinson's disease.
|CBS News||Songbird's Genome Carries Speech Clues||
Scientists have sequenced the complete genome of a songbird - the Australian zebra finch - and say the complex mechanisms by which young birds learn songs from their parents offer insight into human speech acquisition. The international team, led by researchers at Washington University in St. Louis, found that most of the bird's DNA is involved in hearing, imitating, and producing even simple melodies.
|The Independent||Birds hold key to secret of human speech||
A tiny songbird that learns how to sing by listening to its parents could open the way to understanding how children start to talk and what goes wrong when speech defects occur, scientists said.
|St. Louis Post-Dispatch||Finch's singing secrets may give clues on speech||
When we hear a song for the first time, it often seems like it goes in one ear and out the other, sometimes only few catchy words from a chorus leaving much of an impression. But when the Australian zebra finch hears its father sing for the first time, those simple melodies activate large, complex gene networks in the bird's brain, according to new research by an international team of scientists that includes researchers from Washington University and the University of Illinois at Urbana-Champaign.
|GenomeWeb - Registration Required||International Team Sequences Songbird Genome||
An international research team reported online in Nature today that they have sequenced the genome of the zebra finch, Taeniopygia guttata, a songbird used as a model organism in studies of the neuroscience involved in vocal learning and vocal communication.
|WUSTL News||Tweet: Scientists decode songbird's genome||
Nearly all animals make sounds instinctively, but baby songbirds learn to sing in virtually the same way human infants learn to speak: by imitating a parent. Now, an international team of scientists (listed below), led by Washington University School of Medicine in St. Louis, has decoded the genome of a songbird — the Australian zebra finch — to reveal intriguing clues about the genetic basis and evolution of vocal learning.
|GenomeWeb - Registration Required||Wash U to Use $14M ARRA Grant to Double Size, Capacity of Genomics Data Center||
Washington University School of Medicine in St. Louis said this week that it will use a $14.3 million grant from the National Center of Research Resources to double the size of its genomics data center to 32,000 square feet.
|WUSTL News||$14 million in stimulus funds to Washington University for construction||
Washington University School of Medicine in St. Louis has received a $14.3 million grant through the American Recovery and Reinvestment Act (ARRA) to expand its high-powered data center for genomics. The facility’s sophisticated computer networks store massive amounts of genomic data used to identify the genetic origins of cancer and other diseases.
|WUSTL News||Trustees meet, hear reports on cutting-edge medical research||
At the spring meeting of the Board of Trustees, Chancellor Mark S. Wrighton reported on a number of recent developments on the Medical, Danforth and North campuses. Trustees also heard special reports from leading medical faculty on several cutting-edge research and clinical projects.
|NCI Cancer Bulletin||A Conversation about Sequencing Cancer Genomes with Dr. Elaine Mardis||
Dr. Elaine Mardis is co-director of The Genome Center at Washington University in St. Louis. As director of technology development, she leads the center’s efforts to explore progress in next-generation sequencing technologies.
|USA Today||St. Jude, Washington U. launch $65M effort to ID pediatric cancer genes||
Two leading medical centers on Monday launched the largest effort to date to find all of the genetic mutations that cause childhood cancer.
|NCI Cancer Bulletin||St. Jude, Washington University Launch Genome Project for Childhood Cancers||
Researchers at St. Jude Children’s Research Hospital and the Washington University School of Medicine in St. Louis have launched the Pediatric Cancer Genome Project to sequence the genomes of at least 600 children with cancer over the next 3 years. The collaboration marks the first time that whole-genome sequencing will be used on a large scale to discover genetic changes driving pediatric cancers.
|CBC News||Childhood cancer gene search to start||
Researchers plan to map all the genes in childhood tumours to identify mutations that give rise to the cancers.
|St. Louis Public Radio||New $65 million childhood cancer project underway||
ST. LOUIS, MO - Researchers at Washington University in St. Louis are part of a new effort to identify and understand the genetic origins of childhood cancers.
|The Commercial Appeal||St. Jude genome project will seek to crack code of cancer||
Their backgrounds and conditions may vary, but the kids treated by St. Jude Children’s Research Hospital tend to get sick in the same basic ways: White blood cells inexplicably turning into leukemia, or seemingly healthy tissue cells mushrooming into tumors. Now, in a three-year, $65 million research project, St. Jude is joining an unprecedented effort to understand why cells go awry and cause cancer.
|St. Louis Business Journal||Washington U., St. Jude team on $65M pediatric cancer genome project||
Washington University School of Medicine in St. Louis and St. Jude Children’s Hospital in Memphis are teaming up to sequence the genomes of 600 children with pediatric cancer in the hope of identifying the genetic changes that cause some of the world’s deadliest childhood cancers.
|KMOV News||Research seeks cause of childhood cancers||
Researchers in St. Louis and Memphis, Tenn., are launching the largest-ever attempt to identify and understand the genetic origins of childhood cancers.
|WUSTL News||Washington University, St. Jude team to unravel genetic basis of childhood cancers||
Washington University School of Medicine in St. Louis and St. Jude Children's Research Hospital have announced an unprecedented effort to identify the genetic changes that give rise to some of the world’s deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients, who have contributed tumor samples for this historic effort.
|New York Times||Male Chromosome May Evolve Fastest||
A new look at the human Y chromosome has overturned longstanding ideas about its evolutionary history. Far from being in a state of decay, the Y chromosome is the fastest-changing part of the human genome and is constantly renewing itself.
|Siteman Cancer Center||Decoding the Genetics of Cancer (Podcast)||
Research into the genetics of cancer has rapidly expanded in the last few years with the aid of new equipment and new techniques like those pioneered by the The Genome Center at Washington University School of Medicine in St. Louis. In this edition of Breakthroughs in Cancer Research, Genome Center director, Richard Wilson, PhD, explains not only the basics of genetic research but also what scientists hope to learn from studying the genetic origins of cancer and how they hope to apply those discoveries to the treatment of patients in the future.
|Washington Post||Scientists have high hopes for corn genome||
Now the scientific world has at hand the complete genome sequence of corn, announced by researchers who have collaborated over the past four years and published their results Thursday. A package of 14 research papers in Science and PLoS Genetics accompanying the genome release suggests corn still has some useful secrets to reveal.
|St. Louis Post-Dispatch||Scientists unravel the genetic code of corn||
A team of scientists led by researchers at Washington University has completed a detailed "blueprint" of the genetic structure of corn, a breakthrough in understanding the complex biological underpinnings of one of the world's most important crops.
|WUSTL News||Amaizeing: Corn genome decoded||
In recent years, scientists have decoded the DNA of humans and a menagerie of creatures but none with genes as complex as a stalk of corn, the latest genome to be unraveled. A team of scientists led by The Genome Center at Washington University School of Medicine in St. Louis published the completed corn genome in the Nov. 20 journal Science, an accomplishment that will speed efforts to develop better crop varieties to meet the world's growing demands for food, livestock feed and fuel.
|WUSTL News||Washington University awarded $80 million in stimulus grants||
Washington University has been awarded nearly $80 million in funding from the 2009 American Recovery and Re-investment Act (ARRA) to support research across a broad range of projects, including cancer, Alzheimer's disease, renewable energy, diabetes and climate change.
|WUSTL News||Genome Center's data facility gets LEED Gold certification||
The Genome Center's new data facility has received Leadership in Energy and Environmental Design (LEED) Gold certification from the U.S. Green Building Council. The designation makes it the first LEED Gold-certified building on the School of Medicine campus and the only data center in the St. Louis region to attain LEED Gold status.
|GenomeWeb News||New BreakDancer Algorithm Performs High-Res Mapping of Indels, More||
With the cost of sequencing coming down, looking for structural variation genome-wide is getting easier. Typically, to find structural variants — everything that isn't a SNP, including indels, copy number variants, inversions, and translocations — people have been using array CGH, among other array-based tools. Now, however, high-throughput sequencing analysis is possible and provides a way to predict structural variants more accurately. Challenges to data analysis remain, though, including how to incorporate short inserts into current mapping algorithms and how to take into account varying coverage, insert size, and read length data from different next-gen platforms. To this end, work out of Elaine Mardis' lab led by Ken Chen has resulted in a new set of algorithms that improve common variant detection and detection of somatic variants in tumor versus normal samples.
|Bio-IT World||David Dooling: Gangbusters at the Genome Center||
David Dooling joined The Genome Center at Washington University at St Louis in 2001 from Exxon Mobil, where he’d been developing chemical reaction models. He started as a programmer, writing a lot of software, with no life science familiarity, and picked things up as he went along. He now oversees about half of the informatics group, including Laboratory Information Management Systems (LIMS); the Analysis Developers group, which creates an automated pipeline for the bioinformaticians; and the IT group—infrastructure, network computing, and storage. Kevin Davies spoke to Dooling the same week as his group published the second cancer genome paper, in the New England Journal of Medicine, an important study that identified recurrent mutations in genes not previously associated with acute myeloid leukemia (AML).
|Bio-IT World||Second Cancer Genome Reveals Pros of Genome-Wide Approach||
Researchers at Washington University in St. Louis have sequenced the second acute myloid leukemia (AML) cancer genome with whole genome sequencing, and have identified two mutations previously unassociated with AML. The results were published online in the New England Journal of Medicine on Wednesday.
|BBC News||Cancer gene complexity revealed||
Scientists have shown just how mind-bogglingly complex are the genetics underpinning the development of cancer.
|Cancer Research UK||Scientists sequence genome of second patient with AML||
US scientists have decoded the complete DNA sequence - or 'genome' - of a second patient with acute myeloid leukaemia (AML), following on from the first such achievement last year.
|WUSTL News||Decoding leukemia patient genome leads scientists to mutations in other patients||
Decoding the complete DNA of cancer patients is giving scientists at Washington University School of Medicine in St. Louis a clearer picture of the complexity of the disease and allowing them to see intriguing and unexpected genetic relationships among patients.
|O'Reilly Radar||Sequencing a Genome a Week||
The Human Genome Project took 13 years to fully sequence a single human's genetic information. At Washington University's Genome Center, they can now do one in a week.
|WUSTL Video release||NIH grants to fund important microbiome research at WUSM||
Trillions of "good" bacteria live inside the human body. The NIH's $42 million Human Microbiome Project is aimed at uncovering the role of these microbes in human health and disease.
|U.S. News & World Report||Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure||
In 2006, only three years after helping to decode the human genome, Elaine Mardis and Richard Wilson were running out of money.
|GenomeWeb News||Roche Applied Sciences Awards Two 10 Gigabase Sequencing Grants||
Roche Applied Sciences announced today that it is awarding two 10 Gigabase genome sequencing grants — one to a North American research team and another to a group of researchers in Europe.
|GenomeWeb News||NIH Awards $42M for More Human Microbiome Studies||
Researchers studying the microbes that live on and inside the human body will receive $42 million in new grants from the National Institutes of Health to fund the Human Microbiome Project, NIH said today.
|GenomeWeb News||NIH Awards $28.6M to Three Sequencing Centers as Part of $42M Round for Human Microbiome Project||
The National Institutes of Health said today that it has awarded $28.6 million in total to three large-scale sequencing centers to sequence microorganisms for the Human Microbiome Project over the next four years.
|NIH News||NIH Expands Human Microbiome Project; Funds Sequencing Centers and Disease Projects||
The Human Microbiome Project has awarded more than $42 million to expand its exploration of how the trillions of microscopic organisms that live in or on our bodies affect our health.
|WUSTL News||$19 million to WU scientists to decode microbe DNA and explore links to disease||
The National Institutes of Health (NIH) has awarded scientists at Washington University School of Medicine in St. Louis four grants totaling $19 million to explore the trillions of microbes that inhabit the human body and determine how they contribute to good health and disease.
|The Genome Center||New Genome Web Site||
The Genome Center at Washington University School of Medicine has a new web site.
|St Louis Magazine||Healthy Living: The Code Breakers||
“That’s it!” exclaims Dr. Richard Wilson, director of Washington University’s Genome Center and professor of genetics, jabbing his index finger at a piece of paper containing a strange pattern of dots.
|WUSTL Outlook||Dangerous Transformations||
The first-ever full-genome analysis of one cancer patient becomes a priceless legacy. Understanding the dynamic gene mutations that eventually took her life will mean better diagnoses and treatments in the future.
|GenomeWeb News||Researchers Finding Mutations in Second AML Genome||
Researchers are wrapping up their analysis of the second acute myeloid leukemia genome, Elaine Mardis, co-director of Washington University's Genome Sequencing Center, told attendees at the American Association for Cancer Research meeting in Denver yesterday.
|Science Magazine||Life Science Technologies||
In November 2008 Elaine Mardis of Washington University in St. Louis and colleagues published the complete genome sequence of an individual with acute myeloid leukemia. Coming just a few years after the decade-long, multibillion dollar Human Genome Project, the paper was remarkable on several levels. For one thing, the team sequenced two human genomes, both cancerous and normal, some 140 billion bases in all. More impressive, though, was what the study omitted: the 50 human genomes Mardis sequenced that year (albeit not as deeply) for the 1,000 Genomes Project. "It's like a whole new world," she says. Welcome to the sequencing frontier.
|GenomeWeb News||Launch Pad for Rising Stars||
Rick Wilson can proudly claim to have been part of the breakthrough that led to the sequencing of the first human genome. In fact, Wilson's genome center at the Washington University School of Medicine helped provide more than a quarter of the sequence data for the Human Genome Project.
|GenomeWeb News||The Genomic Basis of Cancer||
Cancer is a disease of genes and of pathways, says Li Ding, a researcher at the genome center at Washington University in St. Louis. As head of the medical genomics group, Ding works to uncover the genomic changes that lead up to and are associated with human cancer. In particular, she is part of both the Tumor Sequencing Project and the Cancer Genome Atlas efforts. "My research mostly focuses on identifying the genomic alteration associated with human cancer," Ding says.
|Business Wire||The Genome Center at Washington University Scales-Up on Illumina Sequencers||
llumina, Inc. (NASDAQ:ILMN) announced today that it has reached an agreement in principle for the Genome Center at Washington University School of Medicine in St. Louis to acquire 21 genome analyzers over the next several months to support the Center's expanding research initiatives. Once the scale-up is complete, the Center will have an installed base of 35 Genome Analyzers. The added capacity, along with the continued improvements to the Genome Analyzer platform, will allow the Genome Center to sequence in the order of one human genome per day at 25x coverage.
|WUSTL News||Research-based undergraduate course expands beyond WUSTL||
Washington University in St. Louis is in the spotlight for its pivotal role in the Genomics Education Partnership (GEP), a collaborative effort to provide research experience in genomics to undergraduate classrooms across the country.
|CBS Evening News Video||Scientists Decode Cancer Cell DNA||
Scientists reported decoding the entire genetics of a cancer cell. They did it by analyzing the cells of a woman with leukemia, reports CBS News medical correspondent Dr. Jon LaPook.
|WUSTL News||Discovery of genes linked to lung cancer opens door to personalized treatment||
Working as part of a multi-institutional collaboration, School of Medicine scientists have assembled the most complete catalog to date of the genetic changes underlying the most common form of lung cancer. The research, published Oct. 23 in Nature, helps lay the foundation for more personalized diagnosis and treatment of a disease that is the leading cause of U.S. cancer deaths.
|WUSTL News||Washington University scientists first to sequence genome of cancer patient||
For the first time, scientists have decoded the complete DNA of a cancer patient and traced her disease - acute myelogenous leukemia - to its genetic roots. A large research team at the Genome Sequencing Center and the Siteman Cancer Center at Washington University School of Medicine in St. Louis and Barnes-Jewish Hospital sequenced the genome of the patient - a woman in her 50s who ultimately died of her disease - and the genome of her leukemia cells, to identify genetic changes unique to her cancer.
|Washington Post||First-ever mapping of cancer patient's genome||
In a genetics first, researchers report that they have decoded the complete DNA sequence of a person with acute myelogenous leukemia.
|Reuters||A cancer patient's genome decoded for first time||
Scientists for the first time have decoded the entire genome of a cancer patient, identifying a series of genes never before linked to the type of white blood cell cancer that ultimately killed the woman.
|New York Times||Scientists Decode Set of Cancer Genes||
For the first time, researchers have decoded all the genes of a person with cancer and found a set of mutations that may have caused the disease or aided its progression.
|Washington Post||Researchers find more genes linked to lung cancer||
Researchers have identified 26 genes associated with the most common type of lung cancer, adenocarcinoma -- more than doubling the number of genes known to play a role in the deadly disease.
|Los Angeles Times||Lung cancers involve many different genetic mutations||
Twenty-six different genes are frequently mutated in the most common form of lung cancer, lung adenocarcinoma, according to a study published in the journal Nature. That more than doubles in one swoop the number of genes known to be implicated in this cancer.
|WUSTL News||Scientists find new genes linked to lung cancer||
Working as part of a multi-institutional collaboration, scientists at Washington University School of Medicine in St. Louis have assembled the most complete catalog to date of the genetic changes underlying the most common form of lung cancer.
|WUSTL News||Worm genome offers clues to evolution of parasitism||
The genome of a humble worm that dines on the microbial organisms covering the carcasses of dead beetles may provide clues to the evolution of parasitic worms, including those that infect humans, say scientists at Washington University School of Medicine in St. Louis and the Max-Planck Institute for Developmental Biology in Germany.
|WUSTL News||Is bacterium renewable source of energy?||
A team of researchers headed by biologists at Washington University has sequenced the genome of a unique bacterium that manages two disparate operations — photosynthesis and nitrogen fixation — in one little cell during two distinct cycles daily.
|WUSTL News||Genome technology wizard||
Those of us who are bewildered by the furious pace of changing technology wouldn’t want to walk in the shoes of Elaine R. Mardis, Ph.D., co-director of the Genome Sequencing Center (GSC).
|USA Today||Gene domino effect behind brain, pancreatic tumors||
Scientists have mapped the cascade of genetic changes that turn normal cells in the brain and pancreas into two of the most lethal cancers. The result points to a new approach for fighting tumors and maybe even catching them sooner. Genes blamed for one person's brain tumor were different from the culprits for the next patient, making the puzzle of cancer genetics even more complicated.
|National Cancer Institute||The Cancer Genome Atlas Reports First Results Of Comprehensive Study of Brain Tumors||
The Cancer Genome Atlas (TCGA) Research Network, a collaborative effort funded by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), today reported the first results of its large-scale, comprehensive study of the most common form of brain cancer, glioblastoma (GBM). In a paper published Sept. 4, 2008, in the advance online edition of the journal Nature, the TCGA team describes the discovery of new genetic mutations and other types of DNA alterations with potential implications for the diagnosis and treatment of GBM.
|WUSTL News||Team of scientists uncovers genetic mutations linked to aggressive brain tumor||
Scientists at Washington University School of Medicine in St. Louis, working as part of a large-scale federally funded research collaboration, have discovered new genetic mutations and molecular pathways underlying glioblastoma, the most common form of brain cancer and the most aggressive.
|GenomeWeb News||George Weinstock Discusses Getting the Human Microbiome Project on the Roadmap||
George Weinstock has been associate director of the Genome Center at Washington University since January. He joined the center from Baylor College of Medicine’s Human Genome Sequencing Center, which he co-directed since 1998.
|Genome Reference Consortium||The Genome Center at Washington University is a member of the recently established Genome Reference Center Consortium (GRC).||
In order to improve the representation of the reference human genome we have formed the Genome Reference Consortium (GRC). The goal of this group is to correct the small number of regions in the reference that are currently misrepresented, to close as many remaining gaps as possible and to produce alternative assemblies of structurally variant loci when necessary. We will provide mechanisms by which the scientific community can report loci in need of further review.
|WUSTL News||Platypus genome explains animal's peculiar features; holds clues to evolution of mammals||
The duck-billed platypus: part bird, part reptile, part mammal - and the genome to prove it. An international consortium of scientists, led by the School of Medicine, has decoded the genome of the platypus, showing that the animal's peculiar mix of features is reflected in its DNA.
|WUSTL News||University celebrates National DNA Day||
National DNA Day is April 25. The day celebrates a most remarkable molecule, one that holds the instructions for life: DNA. DNA Day was created in 2003 to commemorate the completion of the Human Genome Project and the 50th anniversary of James Watson's and Francis Crick's discovery of DNA's double helical structure.
|WUSTL News||Wilson leads quest to reveal the genome's secrets||
In his youth, Richard K. Wilson, Ph.D., had two heroes: He lived with one, and the other had a Nobel Prize. Wilson's father was a high-school biology teacher who inspired in his son a passion for science. And James Watson, Ph.D., co-discoverer of the double-helical structure of DNA, inspired in Wilson a decades-long fascination with the genetic code that would shape his career.
|MSNBC||Researchers map corn plant's genome||
Scientists at universities and corporations are about to get a major leg up in their tireless - and profitable - effort to reinvent the corn plant. A group of researchers led by Washington University in St. Louis have mapped out the corn plant's massive genome, and is posting the research on the Internet.
|St. Louis Public Radio||Corn Genome Mapped||
Scientists at the Genome Sequencing Center at Washington University have sequenced the corn genome. They say the sequencing will help researchers develop better crop varieties and help companies like Monsanto look for genes that make corn more nutritious or more efficient for ethanol production.
|WUSTL News||Washington University unveils draft sequence of corn genome||
A team of scientists led by Washington University in St. Louis has begun to unlock the genetic secrets of corn, a crop vital to U.S. agriculture. The researchers have completed a working draft of the corn genome, an accomplishment that should accelerate efforts to develop better crop varieties to meet society's growing demands for food, livestock feed and fuel.
|Record||1,000 human genomes to be sequenced||
The School of Medicine will play a leading role in an international collaboration to sequence the genomes of 1,000 individuals by participating in the ambitious 1,000 Genomes Project, designed to create the most detailed picture to date of human genetic variation and assist in the identification of many genetic factors underlying common diseases.
|New York Times||The race to read genomes on a shoestring, relatively speaking||
If the cost of sequencing a human genome can drop to $1,000 or below, experts say it would start to become feasible to tell what diseases people might be at risk for.
|WUSTL News||Washington University part of major effort to sequence 1,000 human genomes||
Washington University School of Medicine in St. Louis will play a leading role in an international collaboration to sequence the genomes of 1,000 individuals. The ambitious 1000 Genomes Project will create the most detailed picture to date of human genetic variation and likely will identify many genetic factors underlying common diseases.
|NIH News||International Consortium Announces the 1000 Genomes Project||
An international research consortium announced the 1000 Genomes Project, an ambitious effort that will involve sequencing the genomes of at least a thousand people from around the world to create the most detailed and medically useful picture to date of human genetic variation. The project will receive major support from the Wellcome Trust Sanger Institute in Hinxton, England, the Beijing Genomics Institute, Shenzhen (BGI Shenzhen) in China and the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH).
|Outlook||Lab Cultures \---| To get more minorities in scientific research, first get them in the laboratory||
Fewer than 3 percent of PhDs awarded in science, mathematics and engineering go to African-Americans. For Latinos, the numbers are only slightly better. Nationwide, research institutions struggle to entice minorities to obtain advanced science degrees. "The problem is pervasive," says Richard K. Wilson, PhD, director of the School of Medicine's Genome Sequencing Center (GSC). But now a program can at least lure them into the lab. With funding from the National Human Genome Research Institute, the GSC brought eight promising college students ---| all minorities majoring in the sciences ---| to Washington University this summer, where they received their first independent laboratory experience and close mentoring as part of the new Opportunities in Genomics Research program.
|WUSTL Record||Lung cancer's genetic alterations uncovered by genome researchers||
School of Medicine scientists, working as part of an international research team, have completed a massive effort to map the genetic changes underlying the most commonly diagnosed form of lung cancer. The research provides an unprecedented view of the abnormal genetic landscape in lung cancer cells from patients with adenocarcinoma, the most common type of lung cancer in the United States accounting for about 30 percent of cases.
|Washington University researchers help finish genetic map of common lung cancer (St. Louis Public Radio)||Washington University researchers help finish genetic map of common lung cancer (St. Louis Public Radio)||
Researchers have completed a map of the genetic changes underlying a common form of lung cancer called adenocarcinoma. Scientists at Washington University's Genome Sequencing Center participated in international research that uncovered 57 genomic changes that occur frequently in lung cancer patients. Only 15 changes were previously known.
|WUSTL News||Data center construction will support advances in genome sequencing||
An important component of BioMed 21, the Genome Sequencing Center at Washington University in St. Louis is a gene-sequencing powerhouse and one of the four such centers in the world. It specializes in large-scale, high-throughput genome sequencing, supplying data that helps researchers at the School of Medicine identify the genetic factors that contribute to disease. To meet the massive computing needs of the Genome Sequencing Center (GSC), a 16,000 square-foot data center is being constructed on Newstead Avenue across the street from the center's current facility on the medical campus. The data center will support 120 racks of highly dense data storage and computing solutions required by next-generation DNA sequencing technology.
|Uncovering clues as to what happens when we get cancer (St. Louis Public Radio)||Uncovering clues as to what happens when we get cancer (St. Louis Public Radio)||
The Genome Sequencing Center at Washington University is one of three in the country participating in the Cancer Genome Atlas Project. The three-year pilot study seeks to go deep into the blueprint of the human genome to find clues as to what happens when we get cancer.
|National Science Foundation||Secrets of Plant Genomes Revealed||
Plant genome research is already revolutionizing the field of biology. Currently, scientists are unlocking the secrets of some of the most important plants in our lives, including corn, cotton and potatoes. Secrets of Plant Genomes: Revealed! takes viewers on a lively, upbeat journey that explores how these plants got to be the way they are and investigates how we can make better use of them in the future.
|St. Louis Commerce Magazine||SEQUENCING GENOMES - Almost as a Matter of Course||
The Internet might provide a usefully, albeit simplistic, analogy for the amazing technical advances happening at Washington University's Genome Sequencing Center. Dial-up was amazing as you were introduced to the ever growing net. DSL was boggling as more and more information arrived even faster. And higher speed service? Your net-cup ran over as your computer filled with all the cyber goodies you hadn't anticipated receiving back in the recent past of dial-up days presenting you a sudden need for increased memory for the increasing items to be saved with the promise of even greater advances in the indeterminate future.
|Bio-IT World||SNPing Away at Genome-Wide Disease Association Studies||
This year has seen a torrent of reports in scientific journals and mainstream media announcing the results of studies linking a gene variant to an increased risk for common diseases ---| diabetes, Alzheimer's disease, and heart disease, for example. As the New York Times stated recently, "The sudden spate of new genes marks an acceleration, and perhaps a turning point, in the ability to find disease genes."
|WUSTL News||Initial Orangutan and Marmoset Assemblies Completed||
Washington University scientists recently completed initial assemblies of the orangutan and marmoset genomes. Analysis of these genomes and a comparison with human and the other primates will be carried out over the next several months. The National Human Genome Research Institute, one of the National Institutes of Health, funded the sequencing and assembly efforts.
|WUSTL News||Rhesus Monkey Genome Reveals DNA Similarities with Chimps and Humans||
Scientists have decoded the genome of the rhesus macaque monkey and compared it with the genomes of humans and their closest living relatives - the chimps - revealing that the three primate species share about 93 percent of the same DNA.The sequencing was completed by an international consortium of researchers, including scientists at the Genome Sequencing Center at Washington University School of Medicine in St. Louis, and is published in a special section of the April 13 issue of the journal Science. The research was funded by the National Human Genome Research Institute, one of the National Institutes of Health.
|New York Times||The Vanishing Man of the Forest||
ONCE again, I am driving, under the blazing equatorial sun, down an uncomfortable, rutty relic of a road into the interior of central Borneo. With me are two uniformed police men, one armed with a machine gun. The landscape is bleak, no trees, no shade as far as the eye can see. Our mission is to confiscate orangutan orphans whose mothers have been killed as a result of the sweeping forest clearance taking place throughout Borneo.
|NPR||Fat Bacteria in Human Guts Tied to Obesity||
Many people worry about putting on a few pounds during the holiday season. But when you reach for a Christmas cookie, keep in mind that you're not the only one who's going to enjoy that tasty treat: It will also get eaten by the bacteria living in your gut.
|WUSTL News||GSC receives $156 million||
The Genome Sequencing Center at Washington University School of Medicine in St. Louis has been awarded a $156 million, four-year grant to use the powerful tools of DNA sequencing to unlock the secrets of cancer and other human diseases.
|NIH News||NHGRI Funds Large-Scale Sequencing Centers||
The National Human Genome Research Institute (NHGRI) announced the results of the recent competition for support of its three large-scale sequencing centers, strengthening efforts to use the power of DNA sequencing to unlock the genomic secrets of human diseases. Also today, NHGRI and the National Cancer Institute (NCI), both part of the National Institutes of Health (NIH), announced that all three sequencing centers will devote a significant part of their efforts to The Cancer Genome Atlas (TCGA) Pilot Project, which is testing the feasibility of a large-scale, systematic approach to identify important genomic changes involved in cancer.
|Genome Biology||Anticipating the $1,000 genome||
A new generation of DNA-sequencing platforms will become commercially available over the next few years. These instruments will enable re-sequencing of human genomes at a previously unimagined throughput and low cost. Here, I examine why the $1,000 human genome is an important goal for research and clinical diagnostics, and what will be required to achieve it.
|WUSTL News||Gut microbes' partnership helps body extract energy from food, store it as fat||
Researchers studying mutually beneficial interactions between members of our vast community of friendly gut microorganisms have shown that two common organisms collude and collaborate to increase the amount of calories harvested from a class of carbohydrates found in food sweeteners.
|WUSTL News||Scientists solve 30-year-old mystery of mutant mouse's kidney woes||
Researchers seeking insights into kidney failure in human infants have located the source of a 30-year-old mystery mutation that causes similar problems in a mouse line.
|EurekAlert!||Washington University's Sarah Elgin is re-funded by Howard Hughes Medical Institute||
Sarah C. R. Elgin, Ph.D., professor of biology at Washington University in St. Louis, named a 'Howard Hughes Medical Institute (HHMI) Professor' in 2002, is one of eight scientists to have her original grant funding renewed in 2006. In 2002, Elgin was one of 20 'million dollar professors' to get funding when HHMI announced the program. Recently, HHMI announced the awarding of 20 new such professorships in 2006, in addition to renewal funding to help eight of the 2002 group find ways to sustain the parts of their programs that worked best and to disseminate them to the broader community of science educators.
|Record||Solutions sought for carbon sequestration, hydrogen production||
In just six months of collaboration, a Department of Energy "grand challenge project" led by the University has resulted in the sequencing and annotation of a cyanobacterium gene that could yield clues to how environmental conditions influence key carbon fixation processes at the gene-mRNA-protein levels in an organism.
|National Public Radio||Scientists probe the secrets of maize genome||
The Genome Sequencing Center at Washington University is in full swing, sequencing the entire maize genome.
|EurekAlert!||Partnering with community groups improves K-12 science education||
The recent revolution in the life sciences- the sequencing of the human genome, and development of "high throughput" technologies- has created new opportunities for investigation, and created new challenges for educators. Sarah C.R. Elgin, Ph.D., professor of biology; biochemistry and molecular biophysics; and education in Arts & Sciences at Washington University in St. Louis, has been a proponent and creator of partnerships locally and nationwide to improve the life science education both in K-12 schools and at the undergraduate level.
|NIH News||Researchers Assemble Second Non-Human Primate Genome||
A multi-center team has deposited the draft genome sequence of the rhesus macaque monkey into free public databases for use by the worldwide research community, the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH).
|New Genome and Epigenome Projects (St. Louis Public Radio)||New Genome and Epigenome Projects (St. Louis Public Radio)||
Richard Wilson, Director of the Genome Sequencing Center, was interviewed by National Public Radio. He discussed the Cancer Genome Project at Washington University and the importance of epigenetic factors.
|PR Newswire||454 Life Sciences and The Genome Center at Washington University School of Medicine in St. Louis Announce Collaborative Research Plan||
454 Life Sciences Corporation, a majority-owned subsidiary of CuraGen Corporation (Nasdaq: CRGN), and The Genome Center at Washington University School of Medicine in St. Louis today announced a collaborative research plan to sequence disease-causing pathogens and to sequence RNA to analyze gene activity in tissue samples. Research will be performed on the 454 Life Sciences' Genome Sequencer 20 Systems at The Genome Center.
|WUSTL News||Washington University receives $29.5 million to sequence corn genome||
Researchers at the Genome Sequencing Center (GSC) at Washington University School of Medicine in St. Louis will lead the sequencing of the genome of maize, more popularly known to consumers as corn.
|Sequencing Maize (WUSTL News)||Sequencing Maize (WUSTL News)||
Washington University has received $29.5 million to sequence the corn genome. The Genome Sequencing Center has been chosen as the lead institution for a project, jointly sponsored by the National Science Foundation, the U. S. Department of Energy, and the U. S. Department of Agriculture, to sequence the maize genome. Other institutions that will participate are Arizona Genomics Institute (AGI) Tucson, AZ, Cold Spring Harbor Laboratory (CSHL), Cold Spring Harbor, NY, and Iowa State University, Ames Iowa.
|NIH News||New Genome Comparison Finds Chimps, Humans Very Similar at the DNA Level||
The first comprehensive comparison of the genetic blueprints of humans and chimpanzees shows our closest livingrelatives share perfect identity with 96 percent of our DNA sequence, an international research consortium reported.
|NIH News||Scientists Analyze Chromosomes 2 and 4||
Human chromosome 2 is unique to the human lineage in being the product of a head-to-head fusion of two intermediate-sized ancestral chromosomes. Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for genes associated with Wolf-Hirschhorn syndrome, polycystic kidney disease and a form of muscular dystrophy. Here we present approximately 237 million base pairs of sequence for chromosome 2, and 186 million base pairs for chromosome 4, representing more than 99.6% of their euchromatic sequences. Our initial analyses have identified 1,346 protein-coding genes and 1,239 pseudogenes on chromosome 2, and 796 protein-coding genes and 778 pseudogenes on chromosome 4. Extensive analyses confirm the underlying construction of the sequence, and expand our understanding of the structure and evolution of mammalian chromosomes, including gene deserts, segmental duplications and highly variant regions.
|NIH News||Researchers Compare Chicken, Human Genomes||
An international research consortium has found that chickens and humans share more than half of their genes, but that their DNA sequences diverge in ways that may explain some of the important differences between birds and mammals. The consortium's analysis is published in the Dec. 9 issue of the journal Nature.
|Record||WUSTL to play key role in sequencing moss genome||
The University will be directly involved in sequencing the entire genome of the moss Physcomitrella patens at the Joint Genome Institute (JGI) in Walnut Creek, Calif.
|Geneticists Receive $2 Million Grant to Study Parasites That Infect 2 Billion (WUSTL News)||Geneticists Receive $2 Million Grant to Study Parasites That Infect 2 Billion (WUSTL News)||
Scientists at the Genome Sequencing Center (GSC) at Washington University School of Medicine in St. Louis have received a four-year, $2 million National Institutes of Health (NIH) grant to study the genetics of two groups of parasitic roundworms, ascaris and hookworm.
|NIH News||Chicken Genome Assembled||
The National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), today announced that the first draft of the chicken genome sequence has been deposited into free public databases for use by biomedical and agricultural researchers around the globe.
|NIH News||Chimp Genome Assembled by Sequencing Centers||
The National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), today announced the first draft version of the genome sequence of the chimpanzee and its alignment with the human genome. All of the data have been deposited into free public databases and are now available for use by scientists around the world.
|Washington University Launches BioMed 21 (WUSTL News)||Washington University Launches BioMed 21 (WUSTL News)||
Washington University Launches BioMed 21 ---| a $300 Million Biomedical Science Initiative to Transform Genome Research into New Medical Treatments.
|NIH News||NHGRI Funds Next Generation Of Large-Scale Sequencing Centers||
The National Human Genome Research Institute (NHGRI) announced the selection of five centers to carry out a new generation of large-scale sequencing projects designed to maximize the promise of the Human Genome Project and dramatically expand our understanding of human health and disease.
|Record||Y chromosome sequencing sheds light on infertility, mysteries of maleness||
Two studies of the Y chromosome -- the chromosome for maleness -- provide new insights into the mysteries of maleness and the causes and diagnosis of male infertility.
|NIH News||Researchers Discover Use of Novel Mechanism Preserves Y Chromosome Genes||
A detailed analysis of the just-completed sequence of the human Y chromosome - the chromosome that distinguishes males from females - has uncovered a novel mechanism by which it maintains its genetic integrity. The study is published in the current issue of Nature.
|Yeast Genomes Reveal New Sites of Gene Control (WUSTL News)||Yeast Genomes Reveal New Sites of Gene Control (WUSTL News)||
Researchers at Washington University School of Medicine in St. Louis have begun unraveling the network of genes and proteins that regulate the lives of cells. The investigators compared the genome of the yeast Saccharomyces cerevisiae (S. cerevisiae) to those of five other yeast species to identify all the locations at which molecules known as regulatory proteins attach to DNA to turn genes on and off. The study is published in the May 30 issue of the journal Science.
|Record||SARS genome sequenced by researchers||
While most of the world works to contain the spread of the virus that causes severe acute respiratory syndrome (SARS), the Genome Sequencing Center (GSC) in the School of Medicine has become part of the international effort to understand the microbe.
|St. Louis Post Dispatch||SARS efforts may help against bioterrorism||
A combination of new techniques that helped unmask the genetic identity of the SARS virus may help researchers mount defenses against bioterrorism.
|Record||Human Genome Project completed||
University researchers and other members of the International Human Genome Consortium announced the successful completion of the Human Genome Project more than two years ahead of schedule at an April 14 news conference in Washington, D.C.
|Record||The Genome Center Director Wilson says 'best is yet to come'||
With the mapping of the human genome nearly complete, some scientists say that medicine has entered the post-genomics age. But Richard K. Wilson, Ph.D., professor of genetics and of molecular microbiology, disagrees.
|Record||Mouse genome blueprint published||
University researchers, working with a large team of international investigators, have published a draft sequence of the mouse genome -- the genetic blueprint of a mouse -- and an analysis comparing the mouse and human genomes.
|NIH News||Initial Sequencing and Analysis of the Mouse Genome||
The international Mouse Genome Sequencing Consortium announced the publication of a high-quality draft sequence of the mouse genome - the genetic blueprint of a mouse - together with a comparative analysis of the mouse and human genomes describing insights gleaned from the two sequences. The paper appears in the Dec. 5 issue of the journal Nature.
|Record||Johnston, Wilson receive genetics appointments||
H. Mark Johnston, Ph.D., professor of genetics, has been named interim head of the Department of Genetics in the School of Medicine, and Richard K. Wilson, Ph.D., associate professor of genetics and of molecular microbiology, has been named director of the Genome Sequencing Center.
|Record||Draft of mouse genome map now publicly available||
A draft sequence of the mouse genome -- the genetic blueprint for the mouse -- has been completed and now is available to the public through databases accessible on the Internet.
|Record||Draft of mouse genome map now publicly available||
A draft sequence of the mouse genome -- the genetic blueprint for the mouse -- has been completed and now is available to the public through databases accessible on the Internet.
|Record||Waterston wins international Gairdner award||
Robert H. Waterston, M.D., Ph.D., director of the Genome Sequencing Center in the School of Medicine, is one of eight scientists to receive the 2002 Gairdner International Award, which this year recognizes exceptional achievement in genomics science. The Gairdner Foundation of Toronto, Canada, announced the awards April 23. Each winner receives $30,000.
|Record||Waterston awarded first Dan David Prize||
Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor of Genetics, head of the Department of Genetics and director of the School of Medicine's Genome Sequencing Center, has received the first Dan David Prize for achievements that hold great promise for improving the future.
|Record||Genome conference draws experts||
A conference on "The Human Genome Project: Expanding the Conversation" at the School of Medicine's Eric P. Newman Education Center recently brought together scholars from widely divergent disciplines.
|St. Louis Post Dispatch||Genetic scientists debate ethical implications: Washington U. hosts conference||
Human beings are 99.9 percent identical, genetically speaking. It's the 0.1 percent that could make the difference in determining whether people are susceptible to heart disease or cancer or genetic discrimination by insurance companies.
|Record||Genome project conference to bring renowned experts||
The Human Genome Project has raised profound legal, ethical, medical and policy issues. "The Human Genome Project: Expanding the Conversation" at the University's schools of Law and Medicine Jan. 28-29 will assemble scholars from widely divergent disciplines to examine the genomics revolution.
|C. elegans Single Nucleotide Polymorphism Data (The Genome Center)||C. elegans Single Nucleotide Polymorphism Data (The Genome Center)||
Details of the analysis of this data and methodology for mapping has been described in a recent publication: Stephen R. Wicks, Raymond T. Yeh, Warren R. Gish, Robert H. Waterston, Ronald H.A. Plasterk.Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nature Genetics 28:160-164.
|Record||Five yeast genomes sequenced for gene-by-gene comparison||
Researchers in the School of Medicine have sequenced the genomes of five yeast species in only three months' time.
|Record||Salmonella's genetic makeup deciphered by researchers||
Scientists at the School of Medicine have mapped and sequenced the genome for a bacterium that is a leading cause of food poisoning worldwide: Salmonella typhimurium.
|Washington University Magazine||This Is Just the Beginning||
The publications on the human genome sequence in Nature and Science are major milestones in the biomedical revolution begun in 1953 with the discovery of the structure of DNA by Watson and Crick.
|Record||Mouse Sequencing Consortium achieves major DNA milestone||
In only six months, the Mouse Sequencing Consortium (MSC), an international public-private effort to accelerate the sequencing of the mouse genome, has generated enough DNA data to cover the mouse genome three times.
|Record||Arvidson, Waterston receive faculty achievement awards||
For their outstanding academic accomplishments, Raymond E. Arvidson, Ph.D., and Robert H. Waterston, M.D., Ph.D., have been named recipients of faculty achievement awards for 2001.
|Record||Human genome map published by consortium||
The Human Genome Project public consortium an- nounced Monday that it has assembled and published a nearly completed physical map of the human genome --the genetic blueprint for a human being.
|St. Louis Post Dispatch||Age of Discovery Lies Ahead for Researchers of Human Genome||
Scientists in Washington, St. Louis and around the world on Monday celebrated the completion of the first analysis of a rough draft of the human genetic code.
|St. Louis Post Dispatch||Genetic researchers are ready for high gear||
With this week's publication of the rough draft of the human genome, you might think genetics researchers have met their goals. Not so, say scientists in St. Louis.
|St. Louis Post Dispatch||Map assembled at WU was critical to genome project, researchers say||
It's not exactly the Yellow Brick Road, but the Golden Path could lead to far greater things.
|Record||First complete DNA sequence of a plant generated||
School of Medicine researchers are part of a team that has generated the first complete DNA sequence of a plant. The team sequenced the genome of Arabidopsis thaliana, a flowering mustard.
|NHGRI||Public-Private Consortium to Accelerate Sequencing of Mouse Genome||
The National Institutes of Health (NIH), the Wellcome Trust and three private companies today announced they have formed a consortium to speed up the determination of the DNA sequence of the mouse genome. The Mouse Sequencing Consortium will provide $58 million over the next six months to decipher the mouse genetic code.
|New York Times||$58 Million Race Is On to Decode Mouse Genome by February||
With the work on the human genome essentially complete, the National Institutes of Health and others said today that they would spend $58 million to decode the genome of the mouse by February.
|Record||International team looking for genes involved in depression||
Theodore Reich, M.D., the Samuel and Mae S. Ludwig Professor of Psychiatry and professor of genetics at the School of Medicine, will help lead an international team of geneticists in a three-year study attempting to uncover the genetic basis of depression.
|Record||Medical school faculty receive grants totaling $7.4 million for range of studies||
Researchers at the School of Medicine recently have received awards that will fund a wide range of studies.
|Record||The Genome Center receives $5 million grant||
The School of Medicine's Genome Center has received a $5 million grant from The National Human Genome Research Institute. The award will fund the final phase of a collaborative effort to identify variations in the DNA sequence between individuals.
|Record||Milestone: WU geneticists attend celebration at White House||
School of Medicine researchers went to the White House June 26 to help announce the assembly of a working draft of the human genome. Robert H. Waterston, M.D., Ph.D.; Richard K. Wilson, Ph.D.; and Mundeep Sekhon joined scientists from across the nation in celebrating this milestone in the massive effort to decipher the genome --3 billion DNA letters that make the blueprint for the human body. The Genome Sequencing Center at the medical school has contributed approximately one-fourth of the DNA sequence generated by the Human Genome Project, an international public consortium.
|The Scientist||60 Members Elected to NAS||
If fathering an entire discipline qualifies a scientist for membership in the National Academy of Sciences, then Indiana University's Jeffrey Palmer rated election hands down.
|Record||Public consortium launches final phase of genome sequencing||
The Human Genome Project international consortium has announced the official launch of the second and final phase of the human genome sequencing project -- the effort to decipher the 3 billion DNA letters that make the human body. The milestone marks the transition from the initial phase, generating a "working draft" of the human DNA, to the final phase, producing the complete finished sequence.
|Record||NAS elects Waterston||
Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at the School of Medicine, has been elected to the National Academy of Sciences (NAS), one of 60 new members chosen May 2.
|Record||NAS elects Waterston||
Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics at the School of Medicine, has been elected to the National Academy of Sciences (NAS), one of 60 new members chosen May 2. Election to the academy is considered one of the highest honors that can be bestowed on an American scientist or engineer. The newly elected members bring the total number of active members to 1,843.
|St. Louis Post Dispatch||WU scientists say "working draft" of human DNA code is nearly complete||
Scientists at Washington University's Genome Sequencing Center today will begin the second and final phase of deciphering the human genetic code.
|Proceedings of the National Academy of Sciences||New Members and Foreign Associates Elected to the National Academy of Sciences on May 2, 2000||
The Academy has elected 60 new members and 15 foreign associates from 9 countries in recognition of their distinguished and continuing achievements in original research.
|Record||Another milestone is reached in race to map human genome||
An international consortium that includes Washington University School of Medicine as a major partner announced March 29 that 2 billion of the 3 billion chemical letters making up the human genetic instruction book have been deciphered. The medical school contributed about one-fourth of this DNA sequence and is generating more.
|Record||Map of human genes belongs to everyone, says The Genome Center director||
"On March 14, President Bill Clinton and British Prime Minister Tony Blair affirmed their support for the Human Genome Project, which is unraveling the human genetic blueprint," Waterston said. "They gave high praise to the policy of making the emerging map of genetic information freely and immediately available to scientists worldwide.
|St. Louis Post Dispatch||Break in genetic disease that leads to deafness prompts call for shared access to information||
In the early morning of Sept. 13, 1997, Dr. Lorraine Everett noticed something unusual in the DNA data she was checking.
|The Scientist||DNA Chips Enlist in War on Cancer||
The boy had the classic symptoms of acute leukemia--low blood counts and tumor cells circulating in his bloodstream. But the diagnosis was tentative because the tumor cells looked atypical for leukemia.
|Record||Scientists read first 'chapter' unraveling chromosome 22||
An international research team that includes the medical school's Genome Sequencing Center has achieved a scientific milestone: The collaborators have unraveled, for the first time, the genetic code of an entire human chromosome, a chapter of the human genetic instruction book.
|St. Louis Post Dispatch||Scientists have mapped a human chromosome for the first time||
For the first time, scientists have mapped virtually an entire human chromosome, one of the chains of molecules that bear the genetic recipe for human life.
|Record||Billion Base Bash||
Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor of Genetics and head of the Department of Genetics (left), celebrates with the rest of the medical school's Genome Sequencing Center, which Waterston directs.
|Washington Post||Genome Project Reaches Milestone: 1 Billion Units of Information Decoded||
Comparing the effort to unravel all human genes to the push a generation ago that put men on the moon, government leaders yesterday celebrated a milestone in the project: the decoding of 1 billion units of genetic information, roughly a third of the total.
|St. Louis Post Dispatch||Human Genome Project: No rush to collaborate||
The race to map the human genome took a new turn in recent weeks. Representatives from Celera, a privately owned for-profit company, have made overtures to the international, public group of academic researchers suggesting the two groups collaborate. What stands in the way of collaboration is disagreement over who has rights to the genome data.
|New York Times||Rivals Reach Milestones in Genome Race||
Two rival teams racing to decode the human genome have each neared or passed significant milestones. It is hard to tell which team is ahead because they are pursuing the same goal along different paths. But both are apparently on track with ambitious schedules that call for ''first drafts'' of the genome to be completed next spring or summer.
|Record||Mouse next in line for DNA sequencing; new network formed||
The School of Medicine will participate in a major new research program to decipher the genetic makeup of the mouse, one of the most frequently used mammals in medical and behavioral research.
|The Scientist||Are We There Yet? Researchers Differ on When a Genome Sequence Is Complete||
A great deal of fanfare and much celebration greeted the publication of the C. elegans sequence in Science this past December.
|Record||Human Genome Project here gets $218.4 million NIH grant||
The School of Medicine has been awarded the largest grant in the University's history. Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor and head of genetics, will receive a five-year $218.4 million grant from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), including $38 million announced in March.
|WUSTL News||Human DNA Sequencing||
Washington University School of Medicine has been awarded $218.4 for Human DNA Sequencing.
The National Institutes of Health (NIH) announced Monday, March 15, that Washington University School of Medicine is one of three U.S. sites chosen to begin full-scale sequencing of the human genome -- all of the DNA in our chromosomes. Because it contains genes and regulators of gene function, this DNA choreographs the development of a fertilized egg to an adult, tells every cell in our bodies how to function and can cause disease when faulty.
|Record||$3.2 million grant to enhance worm genome sequencing||
Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor and head of genetics, has received a three-year $3.2 million grant from the National Human Genome Research Institute. The funding will permit the Genome Sequencing Center, which Waterston directs, to make information about the genome of the roundworm Caenorhabditis elegans more useful to other scientists.
|Record||Researchers catch the worm||
Collaborators here and in England have obtained the first set of instructions for making an animal by determining the order of the 97 million genetic letters in a worm's DNA. The achievement was reported in the Dec. 11 issue of the journal Science. The announcement, at a press conference at the National Academy of Sciences in Washington, D.C., sparked worldwide media interest and coverage.
|Science||Worming Secrets From the C. elegans Genome||
The near completion of the sequence of the C. elegans genome should provide researchers with a gold mine of information on topics ranging from evolution to gene control
|Record||Genome project gets boost with $26.8 million grant||
Robert H. Waterston, M.D., Ph.D., the James S. McDonnell Professor and head of genetics at the School of Medicine, has received the largest single-year grant in Washington University history -- $26.8 million in funding from the National Human Genome Research Institute. The grant will enable the Genome Sequencing Center, which Waterston directs, to forge ahead with sequencing human DNA.
|Record||Sequencing center hosts conference||
The School of Medicine's Genome Sequencing Center is hosting the Fifth International Conference on Automation in Mapping and DNA Sequencing Wednesday, Oct. 7, through Saturday, Oct. 10, in the Eric P. Newman Center.
|St. Louis Business Journal||Genome Sequencing Center shows power of the Internet||
Every night, the computers at Washington University's Genome Sequencing Center link via the Internet with The Sanger Centre outside Cambridge, England, and spend four or five hours exchanging more than 200 million megabytes of data on human genes.
|Record||Richard Gephardt visits The Genome Center||
As Congress gears up for a major budget debate, House Democratic Leader Richard Gephardt (D-Mo.) came to the School of Medicine March 21 to see how funds from the National Institutes of Health (NIH) are being put to work.
|New York Times||The Struggle to Decipher Human Genes||
IN a drab gray building in the industrial outskirts of St. Louis, a team of some 200 people is working 19 hours a day in pursuit of the ultimate self-knowledge. They are spearheading the effort to sequence the human genome by 2005.
|St. Louis Post Dispatch||WU leads quest to map genetic code||
Washington University researchers are helping to lead what may be the most profound investigation ever of ourselves. The effort, known as the Human Genome Project, is an ambitious and international scientific adventure - a kind of biological moonshot. The $20 billion project has been under way for about a decade.
|Record||Waterston deciphers genetic blueprints||
Robert H. Waterston, M.D., Ph.D., is the James S. McDonnell Professor of Genetics and head of the Department of Genetics in the School of Medicine. He also directs the Genome Sequencing Center, where more than 200 researchers, computer specialists, technicians and students work day and night to sequence DNA.
|Record||NIH grant helps train students||
Washington University has received a five-year $750,000 grant from the National Institutes of Health to train graduate students in computational genome analysis.
|Record||School of Medicine scientists complete map of chromosome X||
School of Medicine researchers have reached a milestone in the history of genetics -- the completion of a high-resolution map of chromosome X.
|St. Louis Business Journal||Wash. U's Waterston tops list of NIH grant recipients||
Dr. Robert Waterston is trying to unravel the mystery of life. Waterston, the James S. McDonnell Professor and head of genetics at Washington University School of Medicine, is principal investigator for projects to decipher the genetic makeup of humans and other organisms.
It seems that hardly a day goes by when we don't hear about a discovery in the field of genetics, whether it's the isolation of a disease-causing gene or progress made in mapping all the genes in the human body. In this hour of Science Friday, we'll look at some of the latest achievements in genetics research, and talk about what questions still need to be answered.
|Record||Genetic blueprint: International collaborators announce complete DNA sequence of yeast||
On April 24, School of Medicine researchers were among the international collaborators who announced that they have deciphered the complete genetic instructions for making a cell of yeast.
|Record||Major grant aids effort to sequence human genome||
The Washington University School of Medicine is one of six recipients of major grants from the National Center for Human Genome Research (NCHGR) at the National Institutes of Health.
|National Human Genome Research Institute (NHGRI)||Pilot Study Explores Feasibility of Sequencing Human DNA||
The National Human Genome Research Institute (NHGRI), a key player in the international Human Genome Project (HGP) and part of the National Institutes of Health (NIH), announced today the launch of an unprecedented pilot study to explore the feasibility of large-scale sequencing of human DNA.
|Human Genome News||Positional Cloning Approach Expedites Gene Hunts (pdf)||
For most scientists, searching for a disease gene means years of laboring over the mapping, cloning, and sequencing processes and considerably less time actually studying the gene and its function.
|Genome Centers Provide Overview: Goals, Accomplishments, Resources Highlighted||
Specialized DOE and NIH human genome research centers foster a multidisciplinary approach for addressing major tasks of the U.S. Human Genome Project.
|Science||A Showdown Over Gene Fragments||
When top genome researchers gathered in Washington, D.C., least week for Science's annual conference on the human genome, they came to pursue different agendas in public and private.
|Human Genome News||Sequencing Groups Report Striking Results (pdf)||
Major accomplishments achieved in two separate sequencing projects recently yielded the longest contiguous stretch of DNA sequence on record and the largest comparative sequence analysis of a biologically important region in humans.