Citrobacter koseri

Habitat

Citrobacter cells are isolated from water, sewage, soils, and food, as well as from the feces of man and other animals, where they may be normal inhabitants. They can be found in urine, sputum, and other clinical specimens. They can sometimes be opportunistic pathogens particularly in immunocompromised patients in hospitals or in infants (Pepperell et al., Antimicrob Agents Chemother. 2002 Nov;46(11):3555-60. and references therein).

Biology

The genus Citrobacter was originally distinguished from other members of the Enterobacteriaceae by its ability to use citrate as a carbon source. Various species of Citrobacter may cause infections in neonate children, and in immunocompromised humans. Citrobacter koseri (formerly called Citrobacter diversus) is best known as the cause of sepsis and meningitis leading to central nervous system (CNS) abscesses in neonates and young infants. The majority of cases are sporadic, with no clear source of infection. A significant number of the infants with abscesses die, and many sustain CNS damage (Doran, Clin Infect Dis. 1999 Feb;28(2):384-94.).

Sequencing Plan

Strain CDC 4225-83 was isolated in 1983 in Maryland where it caused neonatal meningitis. It was provided by Caroline Mohr and Melissa Campbell of CDC. The strain is available from the American Type Culture Collection as ATCC BAA-895 or from the Salmonella Genetic Stock Centre as SGSC4696. The genome is being sequenced to 8X coverage, using plasmid and fosmid libraries, and will be finished to an error rate of less than 1 per 10,000 bases. Automated annotation will be performed and manual annotation will continue in the labs of Michael McClelland and Kenneth Sanderson. This project is funded by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH).

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Contacts

Name	Affiliation
Patrick Minx	The Genome Institute, Washington University School of Medicine
Michael McClelland	Cancer Genetics Program, Sidney Kimmel Cancer Center
Kenneth Sanderson	Salmonella Genetic Stock Centre, University of Calgary

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Sequences & Maps

Assemblies

Name	Date	Description	Blast DBs
Citrobacter_diversus-2.0	Jul 18, 2006	5.6X	contigs supercontigs
Citrobacter_diversus-3.0	Aug 17, 2006	9.1X	contigs supercontigs

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