Ancylostoma caninum
Dog Hookworm
A. caninum, dog hookworm. Credit: Jonathan Eisenback
The Genome Institute and collaborators are sequencing the dog hookworm, Ancylostoma caninum. Hookworm diseases are extremely common in the tropics and sub-tropics, with a disease burden comparable to measles and exceeding that of diabetes and lung cancer.
A. caninum causes disease in dogs resulting often in severe anemia and death. This species, which belongs to the group of parasites most closely related to C. elegans, is a widely used model for hookworm infection in humans.
More Information and Sequencing Plan
Please see Whitepaper (pdf) and Nematode.net page.
Contacts
| Name | Affiliation |
|---|---|
| Makedonka Mitreva | The Genome Institute, Washington University School of Medicine |
| John Hawdon | Department of Microbiology and Tropical Medicine, George Washington University Medical Center |
Publications
Dalzell JJ, McVeigh P, Warnock ND, Mitreva M, Bird DM, Abad P, Fleming CC, Day…
RNAi Effector Diversity in Nematodes.
PLoS Negl Trop Dis. 2011 Jun;5(6):e1176. Epub 2011 Jun 7. PubMed | View Abstract
Gao X, Wang Z, Martin J, Abubucker S, Zhang X, Mitreva M, Hawdon JM.
Identification of hookworm DAF-16/FOXO response elements and direct gene targets.
PLoS One. 2010 Aug 19;5(8):e12289. PubMed | View Abstract
Wang Z, Abubucker S, Martin J, Wilson RK, Hawdon J, Mitreva M.
Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.
BMC Genomics. 2010 May 14;11:307. PubMed | View Abstract
Abubucker S, Martin J, Yin Y, Fulton L, Yang SP, Hallsworth-Pepin K, Johnston JS, Hawdon…
The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences.
Mol Biochem Parasitol. 2008 Feb;157(2):187-92. Epub 2007 Nov 9. PubMed | View Abstract
Laha T, Loukas A, Wattanasatitarpa S, Somprakhon J, Kewgrai N, Sithithaworn P, Kaewkes S, Mitreva…
The bandit, a New DNA Transposon from a Hookworm-Possible Horizontal Genetic Transfer between Host and Parasite.
PLoS Negl Trop Dis. 2007 Sep 27;1(1):e35. PubMed | View Abstract
Mitreva M, McCarter JP, Arasu P, Hawdon J, Martin J, Dante M, Wylie T, Xu…
Investigating hookworm genomes by comparative analysis of two Ancylostoma species.
BMC Genomics. 2005 Apr 26;6(1):58. PubMed | View Abstract
