Developed in collaboration with leading researchers, the MEEBO (Mouse Exonic Evidence Based Oligonucleotide) set contains a collection of oligo probes, largely derived from constitutively expressed exons, allowing interrogation of almost 25,000 mouse genes. The set was designed to enable study of mouse transcription patterns and, as broadly as possible, alternative splicing.

An exon-centric design allows the differentiation of constitutively expressed versus alternatively expressed exons. This design also supports comparative genome hybridization (CGH) analysis. In addition to the exon-centric probes, the set contains an extensive assortment of controls that facilitate accurate evaluation of expression results.

We have printed and tested the chip using off the shelf mouse liver and muscle total RNA. Here is our protocol and a sample of the results. Here is the poster we recently presented at the 2005 Chips to Hits.

These chips are available for anyone who would like to use them and will be sold at cost.