| Dr. Wendl is interested in the development and application of mathematical theory and computational methods at the interface of biology, physics, and engineering, especially for those problems that relate strongly to genomics and genetics. He has focused on a number of topics, including the fluid physics of low-Reynolds number flow devices used in biological lab work, probabilistic modeling of the shotgun DNA sequencing method, processing and analysis algorithms for shotgun data, and combinatorial approaches for solving bioinformatics problems in DNA mapping and shotgun sequencing. Wendl is also collaborating with other scientists at the School of Medicine to develop a large-scale analysis pipeline for medical sequencing data. |
- Wendl, M. C. (2005) ``Occupancy Modeling of Coverage Distribution for Whole Genome Shotgun DNA Sequencing'', Bulletin of Mathematical Biology, In Press.
- Wendl, M. C. (2005) ``Probabilistic Assessment of Clone Overlaps in DNA Fingerprint Mapping via a priori Models'', Journal of Computational Biology,12 (3), 283-297. Pubmed
- Hillier, L. W. et al. (2005) ``Generation and Annotation of the DNA Sequences of Human Chromosomes 2 and 4'', Nature, 434 (7034), 724-731. Pubmed
- Wendl, M. C. and Yang, S. P. (2004) ``Gap Statistics for Whole Genome Shotgun DNA Sequencing Projects'', Bioinformatics, 20 (10), 1527-1534. Pubmed
- Wendl, M. C. (2003) ``Collision Probability Between Sets of Random Variables'', Statistics & Probability Letters, 64 (3), 249-254.
- Hillier, L. W. et al. (2003) ``The DNA Sequence of Human Chromosome 7'', Nature, 424 (6945), 157-164. Pubmed
- Wendl, M. C. and Waterston, R. H. (2002) ``Generalized Gap Model for Bacterial Artificial Chromosome Clone Fingerprint Mapping and Shotgun Sequencing'', Genome Research, 12 (12), 1943-1949. Pubmed
- Wendl, M. C. (2001) ``Mathematical Analysis of Coaxial Disk Cellular Shear Loading Devices'', Review of Scientific Instruments, 72 (11), 4212-4217.
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